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Updated: Jul 10, 2026

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
Vascular Health and Gender-Affirming Hormone Therapy: The Immune System in Motion
Jeimison D Santos1, Jefferson Elias-Oliveira2, Ualter G Cipriano2
1Department of Pharmacology, Ribeirao Preto Medical School, University of São Paulo, Brazil. (J.D.S., P.V.-P., R.C.T.).
Gender-affirming hormone therapy affects vascular and immune systems, potentially altering cardiovascular health in transgender individuals. Further research is needed to understand these complex interactions for improved care.
Area of Science:
- Endocrinology
- Immunology
- Cardiovascular Science
- Transgender Health
Background:
- Sex hormones significantly impact cardiovascular homeostasis.
- Understanding the cardiovascular and immunologic effects of gender-affirming hormone therapy (GAHT) is crucial for transgender health.
Purpose of the Study:
- To review the impact of GAHT on vascular function and the immune system in transgender individuals.
- To explore how these changes influence cardiovascular performance and health outcomes.
Main Methods:
- Literature review of studies investigating GAHT's effects on vascular and immune markers.
- Analysis of factors modulating inflammatory states and cardiovascular health in transgender populations.
Main Results:
- GAHT alters leukocyte activation and cytokine secretion, impacting vascular responsiveness differently in feminizing and masculinizing regimens.
- Changes in gut microbiome, body composition, sex chromosomes, and environmental stressors may modulate inflammatory states.
Conclusions:
- Limited data highlight research gaps and inconsistent findings regarding GAHT's cardiovascular and immunologic effects.
- Further research is essential to optimize therapeutic strategies, improve cardiovascular health, and promote inclusive clinical practices for transgender individuals.
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