Related Experiment Video
Updated: Jul 10, 2026
07:34
Perceptual and Category Processing of the Uncanny Valley Hypothesis' Dimension of Human Likeness: Some Methodological Issues
Published on: June 3, 2013
Beyond discrimination: calibration and decision utility are required before GREAT can guide individual ECT decisions
Juan Carlos Munguia1, Yolly Molina1, Patricia Soriano2
1Faculty of Medical Sciences, https://ror.org/03xyve152National Autonomous University of Honduras, Honduras.
Bjpsych Open
|July 9, 2026
Summary
The GREAT instrument shows promise for predicting electroconvulsive therapy response in unipolar depression. Further validation is needed before widespread clinical use.
Area of Science:
- Psychiatry and Mental Health
- Clinical Prediction Tools
Background:
- Unipolar depression treatment response prediction is crucial for effective patient care.
- Electroconvulsive therapy (ECT) is an effective treatment for severe depression.
- Predictive instruments can optimize ECT selection and outcomes.
Purpose of the Study:
- To evaluate the GREAT instrument for predicting ECT response in unipolar depression.
- To assess the discriminatory validity of the GREAT instrument.
Main Methods:
- Development and validation of the GREAT, a seven-item clinical instrument.
- Statistical analysis of discriminatory validity using Area Under the Curve (AUC).
Main Results:
- The GREAT instrument demonstrated promising discriminatory validity with an AUC of 0.841.
- Identified methodological limitations including absent calibration and limited sample representativeness.
Conclusions:
- The GREAT instrument shows potential for predicting ECT response in unipolar depression.
- Methodological gaps require addressing to support individual clinical decision-making.
- Further research is needed to quantify the incremental value of GREAT.
Related Concept Videos
01:20Decision Making
Decision-making is a fundamental cognitive process that involves evaluating alternatives and selecting among them. This process can range from simple choices, such as deciding what to wear, to complex decisions, like choosing a major in college or a career path. The complexity of the decision often dictates the approach we use, which can be broadly categorized into two types: automatic and controlled decision-making.
Automatic decision-making is fast, intuitive, and relies on gut feelings...
Automatic decision-making is fast, intuitive, and relies on gut feelings...
01:14Decision Making: Traditional Method
The process of hypothesis testing based on the traditional method includes calculating the critical value, testing the value of the test statistic using the sample data, and interpreting these values.
First, a specific claim about the population parameter is decided based on the research question and is stated in a simple form. Further, an opposing statement to this claim is also stated. These statements can act as null and alternative hypotheses, out of which a null hypothesis would be a...
First, a specific claim about the population parameter is decided based on the research question and is stated in a simple form. Further, an opposing statement to this claim is also stated. These statements can act as null and alternative hypotheses, out of which a null hypothesis would be a...
01:27Halo Effect
The halo effect is a cognitive bias in which an individual's overall impression influences judgments about their specific traits. This psychological phenomenon leads people to associate positive characteristics with those they perceive as generally good and negative characteristics with those they view as bad. This effect is particularly influential in social perception, professional evaluations, and decision-making processes.The Psychological Basis of the Halo EffectThe halo effect is rooted...
01:09Decision Making: P-value Method
The process of hypothesis testing based on the P-value method includes calculating the P- value using the sample data and interpreting it.
First, a specific claim about the population parameter is proposed. The claim is based on the research question and is stated in a simple form. Further, an opposing statement to the claim is also stated. These statements can act as null and alternative hypotheses: a null hypothesis would be a neutral statement while the alternative hypothesis can have a...
First, a specific claim about the population parameter is proposed. The claim is based on the research question and is stated in a simple form. Further, an opposing statement to the claim is also stated. These statements can act as null and alternative hypotheses: a null hypothesis would be a neutral statement while the alternative hypothesis can have a...
02:55Stereotypes, Prejudice, and Discrimination
Humans are very diverse and although we share many similarities, we also have many differences. The social groups we belong to help form our identities (Tajfel, 1974). These differences may be difficult for some people to reconcile, which may lead to prejudice toward people who are different. Prejudice is a negative attitude and feeling toward an individual based solely on one’s membership in a particular social group (Allport, 1954; Brown, 2010). Prejudice is common against people who are...
01:24Dosage Regimen: Individualization
Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...