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Published on: January 5, 2017
Preparation, characterization, and preventive effects of ginseng polysaccharide-stabilized selenium nanoparticles
Xiaoxiao Zhou1,2, Tao Chen1,2, Xinru Tang1,2
1SKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian, Liaoning, China.
Aim:
To overcome the poor colloidal stability of selenium nanoparticles (SeNPs) and combine ginseng polysaccharide bioactivity with nano selenium advantages for ulcerative colitis prevention.
Materials And Methods:
Ginseng polysaccharide functionalized SeNPs (GP-SeNPs) were prepared. Particle size, in vitro antioxidant activity, cellular uptake, and protection against H2O2‑induced oxidative stress were assessed. A DSS‑induced colitis mouse model was used to assess preventive effects.
Results:
GP-SeNPs showed smaller particle size (101.00 ± 1.22 nm), strong antioxidant activity, enhanced cellular uptake, and protection against oxidative stress in vitro. In DSS mice, GP-SeNPs alleviated colon shortening, weight loss, disease activity index, pro‑inflammatory cytokine mRNA expression, oxidative stress, and colonic histopathological damage.
Conclusion:
Ginseng polysaccharide functionalization improved the stability and biological performance of SeNPs, supporting their development as functional ingredients for intestinal health protection.