Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endoscopic and Radiological Outcomes of Strictureplasty in Patients With Small Bowel Stricturing Crohn's Disease.

ANZ journal of surgery·2026
Same author

Prenatal diagnosis and estimated penetrance of 15q11.2 BP1-BP2 microdeletion syndrome in a Chinese cohort: a retrospective study and literature review.

Human genomics·2026
Same author

CR1(+) tumor-associated macrophages orchestrate an immunosuppressive niche in hepatocellular carcinoma: a genetic and multi-omics dissection.

Journal of translational medicine·2026
Same author

Solar-Blind Optoelectronic Synaptic Transistor Based on a-IGZO/h-BN/MLG Heterostructure.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Enhanced Sensitivity of Real-Time Intraocular Pressure Monitoring by Integration of a Wrinkled Gold-Based Capacitive Sensor with Parity-Time Symmetry Wireless Technology.

ACS sensors·2026
Same author

Xq28 duplication not F8 inversion: integrated genetic reanalysis redefines prenatal carrier diagnosis.

Scientific reports·2026

Related Experiment Video

Updated: Jul 10, 2026

High Throughput MicroRNA Profiling: Optimized Multiplex qRT-PCR at Nanoliter Scale on the Fluidigm Dynamic ArrayTM IFCs
07:27

High Throughput MicroRNA Profiling: Optimized Multiplex qRT-PCR at Nanoliter Scale on the Fluidigm Dynamic ArrayTM IFCs

Published on: August 3, 2011

Development of a High-Throughput Microarray Platform for Rapid, Low-Cost Expanded Carrier Screening.

Jiazhen Chang1, Na Hao1, Xiya Zhou1

  • 1National Clinical Research Center for Women's Health and Obstetric and Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Prenatal Diagnosis
|July 9, 2026
PubMed
Summary
This summary is machine-generated.

A new microarray platform offers accurate, cost-effective expanded carrier screening (ECS) for genetic variants. This method provides a faster, simpler alternative to next-generation sequencing (NGS) for large-scale population screening.

Keywords:
ECSX‐linkedautosomal recessivemicroarray

More Related Videos

High-throughput Protein Expression Generator Using a Microfluidic Platform
09:26

High-throughput Protein Expression Generator Using a Microfluidic Platform

Published on: August 23, 2012

Cost-Efficient Transcriptomic-Based Drug Screening
06:40

Cost-Efficient Transcriptomic-Based Drug Screening

Published on: February 23, 2024

Related Experiment Videos

Last Updated: Jul 10, 2026

High Throughput MicroRNA Profiling: Optimized Multiplex qRT-PCR at Nanoliter Scale on the Fluidigm Dynamic ArrayTM IFCs
07:27

High Throughput MicroRNA Profiling: Optimized Multiplex qRT-PCR at Nanoliter Scale on the Fluidigm Dynamic ArrayTM IFCs

Published on: August 3, 2011

High-throughput Protein Expression Generator Using a Microfluidic Platform
09:26

High-throughput Protein Expression Generator Using a Microfluidic Platform

Published on: August 23, 2012

Cost-Efficient Transcriptomic-Based Drug Screening
06:40

Cost-Efficient Transcriptomic-Based Drug Screening

Published on: February 23, 2024

Area of Science:

  • Genetics
  • Molecular Biology
  • Bioinformatics

Background:

  • Expanded carrier screening (ECS) is crucial for identifying individuals at risk of passing on genetic disorders.
  • Next-generation sequencing (NGS) is a common method for ECS, but can be costly and time-consuming.
  • Developing cost-effective and efficient screening methods is essential for widespread population screening.

Purpose of the Study:

  • To develop and evaluate a customized microarray-based solution for expanded carrier screening (ECS).
  • To assess the accuracy, cost, and speed of the microarray platform compared to NGS.
  • To determine the suitability of the microarray platform for large-scale population screening.

Main Methods:

  • A custom microarray panel was designed, targeting 8271 variants across 265 high-priority genes.
  • 1051 blood samples from an NGS-based ECS project were used for a blind test of the microarray.
  • Performance was evaluated using sensitivity, specificity, and positive predictive value.

Main Results:

  • The microarray platform achieved 99.5% concordance with NGS results.
  • High sensitivity (99.8%) and specificity (99.8%) were demonstrated.
  • Testing time was reduced to 3-4 days, with cost savings of 94%-96%.

Conclusions:

  • Microarray-based carrier screening is a reliable and cost-effective alternative to NGS.
  • The platform offers a timely solution suitable for large-scale population screening.
  • This method enhances the accessibility and efficiency of genetic carrier screening.