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Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library
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Published on: January 14, 2020

Immunoglobulin binding protein (BiP) forms two types of dimers

Karina New1, Miguel I A Lagos-Espinoza1, Nathalie Casanova-Morales2

  • 1Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile.

Protein Science : a Publication of the Protein Society
|July 9, 2026
PubMed
Summary

Immunoglobulin binding protein (BiP) forms distinct dimers affecting its chaperone activity. These dimers show concentration-dependent behavior, influenced by nucleotides and peptides, revealing new insights into protein regulation.

Keywords:
Hsp70chaperone proteindimerizationendoplasmic reticulummass photometryprotein–protein interactionsproteostasisunfolded protein response

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