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Counteracting vitamin D receptor signaling deficiency rescues subcutaneous adipose loss in aging

Xiangyang Wang1,2, Yihong Song1, Mingkang Jia1

  • 1The Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing, 100871, China.

Protein & Cell
|July 9, 2026
PubMed
Abstract

No abstract available in PubMed .

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Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).