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Updated: Jul 10, 2026

Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Direct electrochemical oxidation of alkylarenes to aryl aldehydes and ketones
Youtian Fu1, Ling Zhang1, Jiahao Li2
1College of Chemistry and Pharmaceutical Engineering, Huanghuai University, Zhumadian 463000, China.
Abstract:
A green and sustainable electrochemical protocol for the direct benzylic C(sp3)-H oxidation of alkylarenes to aryl aldehydes and ketones is developed. The protocol employs potassium persulfate as a co-oxidant under constant current electrolysis. It exhibits broad substrate scope, excellent functional group tolerance, and high site-selectivity without over-oxidation. Mechanistic studies, including 18O-labeling experiments, confirm that water serves as the exclusive oxygen atom donor. This operationally simple approach offers an economical alternative for aldehyde and ketone synthesis.
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