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Published on: July 28, 2018
Utility of Pancreatic Perivascular Adipose Tissue as a CT Imaging Biomarker for Diagnosing Type 2 Diabetes
Anisa V Prasad1,2, Tejas Sudharshan Mathai1, Praveen T S Balamuralikrishna1
1Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD.
Article Highlights:
Pancreatic perivascular adipose tissue (PVAT) is a potentially important but understudied fat depot surrounding vessels supplying the pancreas, and its role in type 2 diabetes mellitus (T2DM) remains unclear. We aimed to quantify pancreatic PVAT automatically on routine abdominal computed tomography (CT) scans and assess whether PVAT-derived imaging biomarkers are associated with T2DM and future T2DM risk. PVAT biomarkers were associated with T2DM and were informative predictors in multivariable models. Exploratory analyses showed similar findings for incident T2DM (disease onset within 4 years of follow-up). PVAT may represent a novel CT-based biomarker for early metabolic dysfunction and T2DM risk stratification.
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