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Updated: Jul 10, 2026
08:16
An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses
Published on: July 7, 2017
Interleukin-8 in health and disease
Chiara Bazzichetto1, Emanuela Dell'Aquila2, Margherita Veroli2
1Preclinical Models and New Therapeutic Agents Unit, IRCCS - Regina Elena National Cancer Institute, Rome, Italy. chiara.bazzichetto@ifo.it.
Molecular Biomedicine
|July 9, 2026
Summary
Interleukin-8 (IL-8) is a key cytokine in disease pathogenesis and a potential biomarker for diagnosis and treatment selection. This review covers IL-8
Area of Science:
- Immunology
- Oncology
- Biomarker Discovery
Background:
- Cytokines mediate cell communication and serve as biomarkers.
- Interleukin-8 (IL-8) plays a significant role in numerous immune disorders and diseases.
- IL-8 is increasingly recognized as a prognostic and predictive biomarker, particularly in cancer immunotherapy.
Purpose of the Study:
- To provide a comprehensive review of preclinical and clinical evidence on IL-8.
- To explore IL-8's role in non-malignant diseases (IBD, sepsis, neuroinflammation, liver, cardiovascular).
- To detail IL-8's pro-tumorigenic functions and implications in cancer, including immunotherapy and gut microbiota interactions.
Main Methods:
- Review of preclinical and clinical evidence on IL-8.
- Analysis of IL-8's involvement in various non-malignant and malignant pathologies.
- Discussion of IL-8 targeting strategies and biomarker potential.
Main Results:
- IL-8 is implicated in the pathogenesis of inflammatory bowel diseases, sepsis, neuroinflammation, liver, and cardiovascular diseases.
- IL-8 promotes tumor growth by shaping the immunosuppressive tumor microenvironment.
- IL-8 serves as a prognostic and predictive biomarker for cancer patients, including those undergoing immunotherapy.
Conclusions:
- IL-8 is a pleiotropic cytokine with critical roles in diverse diseases and cancer.
- Standardization of detection methods and understanding IL-8 production sources are crucial for its clinical application.
- IL-8 holds significant potential as a diagnostic and therapeutic target, especially in oncology and immunotherapy.
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