Related Experiment Video

Updated: Jul 10, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

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Sex Differences in Hypertrophic Cardiomyopathy

Sonu Abraham1, Natalie Tapaskar2, Anu Saji3

  • 1Gill Heart and Vascular Institute, University of Kentucky, Lexington, KY, USA.

Current Cardiology Reports
|July 9, 2026
PubMed

Insights

Women with hypertrophic cardiomyopathy (HCM) face later diagnoses and more severe symptoms than men. Recognizing sex-specific differences is crucial for improving care and outcomes for women with HCM.

Area of Science:

  • Cardiology
  • Sex-based Medicine
  • Cardiovascular Research

Background:

  • Hypertrophic cardiomyopathy (HCM) affects males and females differently.
  • Understanding these sex-based disparities is critical for effective management.

Purpose of the Study:

  • To review current evidence on sex-based differences in hypertrophic cardiomyopathy.
  • To highlight disparities in presentation, progression, outcomes, and management.

Main Methods:

  • Systematic review of contemporary scientific literature.
  • Analysis of studies reporting sex-specific data in HCM.

Main Results:

  • Women with HCM are diagnosed later, present with more severe symptoms, and have greater heart failure burden.
  • Despite similar risks for arrhythmias, women experience worse quality of life and faster progression to advanced heart failure.
  • Current risk assessment tools may underestimate disease severity in women; cardiac myosin inhibitors show promise.

Conclusions:

  • Sex-specific differences significantly influence HCM phenotype, progression, and management.
  • Addressing disparities in care access and clinical trial representation is essential.
  • Individualized care recognizing sex differences is key to improving outcomes for women with HCM.
Abstract

Keywords:
Female sexHeart failureHypertrophic cardiomyopathyLeft ventricular outflow tract obstructionMyosin inhibitorsSex differencesWomen

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