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Related Concept Videos

Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA molecules by RNA...
Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA molecules by RNA...
The Proteasome02:18

The Proteasome

Eukaryotic cells can degrade proteins through several pathways. One of the most important amongst these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. A series of enzymes carry out the ubiquitination of the target proteins - E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
The Proteasome01:13

The Proteasome

Eukaryotic cells can degrade proteins through several pathways. One of the most important among these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. This involves participation of a series of enzymes including— E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3 (ubiquitin...
The Proteasome02:18

The Proteasome

Eukaryotic cells can degrade proteins through several pathways. One of the most important amongst these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. A series of enzymes carry out the ubiquitination of the target proteins - E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
Regulated Protein Degradation02:58

Regulated Protein Degradation

It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...

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Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
05:08

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Developing an Educational Game on Protein Degradation.

Natalia A Szulc1, Wojciech Pokrzywa2

  • 1Laboratory of Protein Metabolism, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland. nszulc@iimcb.gov.pl.

Methods in Molecular Biology (Clifton, N.J.)
|July 9, 2026
PubMed
Summary
This summary is machine-generated.

DEGRADATOR is a 2D game teaching the ubiquitin-proteasome system (UPS). It uses constructivist learning to make protein degradation concepts interactive and understandable for science education.

Keywords:
DEGRADATORGame-based learningProtein degradationScience educationUbiquitin-proteasome system

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Last Updated: Jul 10, 2026

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
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Published on: July 8, 2025

Assays for the Degradation of Misfolded Proteins in Cells
10:56

Assays for the Degradation of Misfolded Proteins in Cells

Published on: August 28, 2016

Tuning Degradation to Achieve Specific and Efficient Protein Depletion
05:11

Tuning Degradation to Achieve Specific and Efficient Protein Depletion

Published on: July 20, 2019

Area of Science:

  • Cellular Biology
  • Biochemistry
  • Educational Technology

Background:

  • The ubiquitin-proteasome system (UPS) is vital for protein degradation but complex to teach.
  • Engaging educational tools are needed to explain intricate cellular pathways.
  • Game-based learning offers a promising approach for science education.

Purpose of the Study:

  • To detail the development of DEGRADATOR, a 2D game for learning the UPS.
  • To present the pedagogical framework and technical implementation of the game.
  • To offer insights for educators and developers on using games for science education.

Main Methods:

  • Constructivist game-based learning principles were applied.
  • The development involved iterative design, beta testing, and user feedback.
  • Molecular mechanisms of the UPS were translated into interactive game elements.

Main Results:

  • DEGRADATOR was developed as an engaging tool for understanding protein degradation.
  • The game effectively translates complex biological processes into an interactive experience.
  • User feedback guided the refinement of the game's educational content and mechanics.

Conclusions:

  • Game-based learning, exemplified by DEGRADATOR, can enhance understanding of complex biological systems like the UPS.
  • The development methodology provides a model for creating educational games in science.
  • DEGRADATOR contributes to improving science education and public understanding of protein degradation.