Related Experiment Video
Updated: Jul 10, 2026
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Systemic Autoimmune Rheumatic Disease-Associated Interstitial Lung Disease: A Pulmonary Perspective on Recent
Gulfem Ozduygu1, Punchalee Kaenmuang2, Alexandra B F Guedes3
1Istanbul Faculty of Medicine, Department of Pulmonary Medicine, Istanbul University, Istanbul, Turkey.
Advances in Therapy
|July 9, 2026
Summary
Systemic autoimmune rheumatic disease-associated interstitial lung disease (SARD-ILD) requires early recognition and tailored management. Current guidelines offer frameworks for screening and treatment, but differences necessitate careful multidisciplinary decision-making.
Area of Science:
- Pulmonology
- Rheumatology
- Radiology
Background:
- Systemic autoimmune rheumatic disease-associated interstitial lung disease (SARD-ILD) is a significant cause of morbidity and mortality.
- Clinical presentation and progression vary based on the underlying rheumatic condition, imaging findings, and disease extent.
Purpose of the Study:
- To review the epidemiology, clinical/radiological phenotypes, and pathobiology of SARD-ILD.
- To critically analyze recent ACR/CHEST and ERS/EULAR guideline recommendations for SARD-ILD management from a pulmonary perspective.
Main Methods:
- Narrative review of existing literature on SARD-ILD.
- Comparative analysis of current international guidelines (ACR/CHEST vs. ERS/EULAR).
Main Results:
- SARD-ILD is common in systemic sclerosis and inflammatory myopathies, impacting outcomes in RA, Sjögren's, and MCTD.
- Guidelines differ in screening, monitoring (risk-based vs. disease-specific HRCT), and management approaches.
- Immunosuppression is standard; antifibrotics are increasingly used for progressive fibrotic disease.
Conclusions:
- Early SARD-ILD detection is crucial to prevent irreversible fibrosis.
- Translating guideline differences into practical, multidisciplinary decisions for screening, monitoring, and treatment is essential.
- Further research is needed, particularly for non-systemic sclerosis SARD-ILD subtypes.
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