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Dearomatization-Triggered Boulton-Katritzky Rearrangement for the Synthesis of 1,3-Diazaspiro[4.5]decane Derivatives
Ziyi Wang1, Tingyao Li1, Ming Zhang1
1Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Zhejiang Key Laboratory of Advanced Catalysis and Adsorption Materials, Zhejiang Normal University, Jinhua 321004, China.
Abstract:
A dearomatization-triggered Boulton-Katritzky rearrangement is reported for the construction of 1,3-diazaspiro[4.5]decane scaffolds. Leveraging a rare carbon-centered nucleophile generated in situ via phenol dearomatization, this metal-free cascade delivers structurally diverse diazaspiro products with high efficiency.
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