Related Experiment Video

Updated: Jul 12, 2026

A Preclinical Model of Exertional Heat Stroke in Mice
08:22

A Preclinical Model of Exertional Heat Stroke in Mice

Published on: July 1, 2021

Correlation of Lactate Dehydrogenase Levels with Arrhythmia in Classic Severe Heatstroke

Fujing Liu1,2, Jing Shi1, Fang Jin3

  • 1Department of Emergency and Critical Care Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Cardiology
|July 9, 2026
PubMed

Insights

Elevated lactate dehydrogenase (LDH) levels are linked to a higher risk of arrhythmia in severe heatstroke patients. LDH also partially mediates the connection between high temperature and heart rhythm disturbances.

Area of Science:

  • Cardiology
  • Emergency Medicine
  • Biochemistry

Background:

  • Arrhythmia incidence and risk factors in severe heatstroke are not well-defined.
  • Understanding these factors is crucial for patient management and outcomes.

Purpose of the Study:

  • To investigate the association between lactate dehydrogenase (LDH) levels and arrhythmia in patients with classic severe heatstroke.
  • To evaluate LDH's predictive value for arrhythmia development.

Main Methods:

  • Retrospective multicenter cohort study of 261 severe heatstroke patients.
  • Logistic regression analyzed the association between natural logarithm-transformed LDH (Ln(LDH)) and arrhythmia.
  • Receiver operating characteristic (ROC) curve analysis assessed predictive performance; mediation analysis explored LDH's role.

Main Results:

  • 30.7% of patients developed arrhythmia.
  • Higher Ln(LDH) was significantly associated with increased arrhythmia risk (OR = 2.871).
  • LDH partially mediated the temperature-arrhythmia relationship (30.5% mediation).

Conclusions:

  • Elevated LDH is a significant risk factor for arrhythmia in severe heatstroke.
  • LDH demonstrates strong predictive potential for arrhythmia in this patient population.
Abstract

Keywords:
ArrhythmiaClassic severe heatstrokeLactate dehydrogenase

More Related Videos

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus08:28

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus

Published on: April 5, 2011

Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Electrocardiogram01:29

Electrocardiogram

An electrocardiogram (ECG or EKG) is a critical diagnostic tool that records the electrical signals produced by the heart during each heartbeat. This recording is achieved through electrodes placed strategically on the arms, legs, and chest. The electrocardiograph amplifies these signals and produces 12 distinct tracings, offering a comprehensive understanding of the heart's electrical activity.
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and the T...
Dysrhythmias V: Evaluating Dysrhythmias01:30

Dysrhythmias V: Evaluating Dysrhythmias

Dysrhythmias, also known as arrhythmias, are disturbances in the heart's rhythm that range from benign to life-threatening. A thorough evaluation is crucial for appropriate management and involves a comprehensive medical history, physical examination, and various diagnostic tests.Medical HistorySymptoms: Collect detailed information on palpitations, dizziness, syncope, chest pain, and fatigue. Note their onset, frequency, and triggers.Previous Cardiac Issues: Document any history of heart...
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective response...
Correlation between ECG and Cardiac Cycle01:25

Correlation between ECG and Cardiac Cycle

The electrical signals recorded on an electrocardiogram (ECG) occur before the mechanical processes of contraction and relaxation during the cardiac cycle.
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...