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Natural Variation in C. elegans 1-Octanol Olfactory Avoidance Behavior.

Emily A Polk1, Robyn E Tanny2, Amanda O Shaver2

  • 1Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260  USA.

G3 (Bethesda, Md.)
|July 9, 2026
PubMed
Summary
This summary is machine-generated.

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Researchers studied natural genetic variation in C. elegans olfaction using wild strains and the aversive odorant 1-octanol. Most wild strains showed similar or reduced avoidance compared to the lab strain, with one QTL linked to this trait.

Area of Science:

  • Neuroscience
  • Genetics
  • Animal Behavior

Background:

  • Chemosensation is crucial for animal behavior, guiding responses to food, environment, and threats.
  • Research often relies on limited lab-adapted strains, potentially missing natural behavioral variation.
  • The nematode C. elegans, particularly the N2 strain, is a model for chemosensory studies.

Purpose of the Study:

  • To investigate natural variation in C. elegans behavioral sensitivity to the aversive odorant 1-octanol.
  • To identify genetic factors contributing to differences in olfactory responses among wild C. elegans strains.

Main Methods:

  • Utilized a global collection of wild C. elegans strains and whole-genome sequencing data.
  • Assessed behavioral sensitivity to 1-octanol across diverse wild strains.
Keywords:
C. elegans1-octanolGWASavoidancebehaviorolfactionwild strain

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  • Performed genome-wide association studies (GWAS) and utilized near-isogenic lines to pinpoint genetic loci.

    • Main Results:

    • Wild C. elegans strains exhibited either similar or reduced avoidance of 1-octanol compared to the reference N2 strain; no hypersensitive strains were observed.
    • A single quantitative trait locus (QTL) on chromosome II was identified and confirmed to be associated with diminished avoidance behavior.
    • This study represents a large-scale investigation into natural genetic variation influencing C. elegans olfaction.

    Conclusions:

    • Natural genetic variation significantly impacts C. elegans olfactory behavior, particularly in response to aversive odorants like 1-octanol.
    • The identified QTL on chromosome II plays a role in modulating behavioral avoidance.
    • This work expands our understanding beyond laboratory strains, highlighting the importance of natural diversity in chemosensory research.