Related Experiment Video
Updated: Jul 12, 2026

Venous Thrombosis Assay in a Mouse Model of Cancer
Published on: January 5, 2024
Unveiling the identification of the genetic features and biological characteristics shared between cervical cancer
Xijin Lin1, Lanting Xie2, Kongfeng Shao1
1Department of Radiation Oncology, Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350005, China.
Objective:
The association between cervical cancer (CC) and venous thromboembolism (VTE) has been well documented, but the underlying molecular characteristics remains unclear. The aim of this study was to explore the shared genetic features and regulatory networks of CC and VTE.
Methods:
Protein-protein interaction was used to identify differentially expressed genes (DEGs) in GEO datasets. Lasso, XGB, GLM, and RF algorithms were used to select hub genes to build predictive nomogram models to examined their diagnostic performance. And, we assessed the immune infiltration characteristics and predicted the sensitivity to chemotherapy via the GDSC/CTRP database.
Results:
We identified two hub genes (RSRC1 and EEF1B2). The predictive nomogram model proved discrimination in the training cohort (AUC = 0.964) and kept performance in the external validation. Single-cell RNA sequencing and immune cell infiltration analyses indicated that RSRC1 and EEF1B2 might modulate the immune microenvironment via macrophages, thereby promoting the development of CC and VTE. Drug sensitivity prediction suggested RSRC1 and EEF1B2 might affect the chemosensitivity of some drugs (p < 0.001).
Conclusion:
This study revealed the comorbid features of CC and VTE. These findings offer new insights into the molecular mechanisms of CC and VTE and might provide preliminary recommendations for diagnosis and treatment.
Related Concept Videos
Venous Thrombosis I: Introduction
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
Venous Thrombosis III: Interprofessional Care
Varicose Veins II: Diagnostic Studies and Interprofessional Care
Pulmonary Embolism I: Introduction
Varicose Veins I: Introduction