Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Awareness during surgery--a new approach.

R S Cormack

    British Journal of Anaesthesia
    |November 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Lorazepam premedication ensures unconsciousness during light anesthesia, unlike morphine. A new test, "time to correct response," reliably measures patient awareness after surgery.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cormack-Lehane classification revisited.

    British journal of anaesthesia·2010
    Same author

    Wrong chi-squared again.

    Annals of the Royal College of Surgeons of England·2009
    Same author

    Missing chi again.

    Annals of the Royal College of Surgeons of England·2009
    Same author

    Intubation training in the real world: a defence of the Northwick Park drill.

    Anaesthesia·2007
    Same author

    Failed intubation in obstetric anaesthesia.

    Anaesthesia·2006
    Same author

    Failed intubation in obstetric anaesthesia.

    Anaesthesia·2006
    Same journal

    Postoperative outcomes in older patients with postoperative delirium in the UK: timing of postoperative delirium screening in the SNAP-3 study. Comment on Br J Anaesth 2026; 136: 1578-87.

    British journal of anaesthesia·2026
    Same journal

    Population pharmacokinetic-pharmacodynamic analysis and dose optimisation of ciprofol in paediatric anaesthesia.

    British journal of anaesthesia·2026
    Same journal

    Global environmental and geo-economic impact of conservative versus liberal oxygen strategies in mechanically ventilated critically ill adults: an ecological country-level analysis.

    British journal of anaesthesia·2026
    Same journal

    Postoperative outcomes in older patients living with frailty and multimorbidity in the UK. Response to Br J Anaesth 2026; 136: 776-7.

    British journal of anaesthesia·2026
    Same journal

    South African Paediatric Surgical Outcomes Study-2 (SAPSOS-2): a prospective multi-centre pre-post study evaluating haemoglobin response to oral iron for iron-deficiency anaemia in children undergoing elective noncardiac surgery.

    British journal of anaesthesia·2026
    Same journal

    Intravenous iron administration and management of adverse events: a systematic review and Network for the Advancement of Patient Blood Management, Haemostasis and Thrombosis consensus recommendations.

    British journal of anaesthesia·2026
    See all related articles

    Area of Science:

    • Anesthesiology
    • Neuroscience
    • Surgical Monitoring

    Background:

    • Assessing patient consciousness during light anesthesia is challenging due to the lack of reliable physical signs.
    • Modern anesthesia techniques aim to minimize side effects while ensuring patient safety and unconsciousness.

    Purpose of the Study:

    • To evaluate the efficacy of lorazepam versus morphine as premedication for maintaining unconsciousness during nitrous oxide anesthesia.
    • To introduce and validate a new method for assessing patient awareness post-surgery.

    Main Methods:

    • Development of the "time to correct response" (TCR) test, measuring the earliest patient response to verbal commands after anesthetic withdrawal.
    • Comparison of lorazepam (4 mg/70 kg) and morphine (10 mg) premedication in two groups of patients undergoing abdominal surgery.

    Related Experiment Videos

    Main Results:

    • Lorazepam premedication significantly improved unconsciousness compared to morphine (P < 0.01).
    • All patients receiving lorazepam could respond to a verbal request, such as holding up their head, shortly after surgery.

    Conclusions:

    • Lorazepam is superior to morphine for ensuring unconsciousness in patients receiving light nitrous oxide anesthesia.
    • The TCR test provides a reliable measure of consciousness, allowing for the benefits of light anesthesia to be maintained safely.