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Related Concept Videos

Standards of Care II01:19

Standards of Care II

Nurses bear specific legal responsibilities under several federal statutes, including:
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Breast Cancer, Version 4.2026, NCCN Clinical Practice Guidelines In Oncology.

William J Gradishar1, Meena S Moran2, Jame Abraham3

  • 11Robert H. Lurie Comprehensive Cancer Center of Northwestern University.

Journal of the National Comprehensive Cancer Network : JNCCN
|July 9, 2026
PubMed
Summary
This summary is machine-generated.

The National Comprehensive Cancer Network (NCCN) Guidelines offer updated breast cancer treatment strategies for recurrent or stage IV metastatic breast cancer. Recommendations are tailored by tumor biology and patient history, emphasizing supportive care and clinical trial enrollment.

Related Experiment Videos

Area of Science:

  • Oncology
  • Clinical Practice Guidelines

Background:

  • The NCCN Guidelines for Breast Cancer provide comprehensive management recommendations.
  • Annual updates ensure guidelines reflect the latest clinical trial evidence.

Purpose of the Study:

  • To present NCCN's recommendations for managing recurrent or stage IV (M1) metastatic breast cancer.
  • To summarize treatment strategies based on tumor biology and clinical factors.

Main Methods:

  • Review of recently published clinical trials by an expert panel.
  • Stratification of treatment recommendations by hormone receptor status, HER2 expression, prior therapy, and disease-free interval.

Main Results:

  • Treatment strategies for metastatic breast cancer are outlined.
  • Recommendations consider tumor characteristics and patient history for personalized care.

Conclusions:

  • Management of metastatic breast cancer involves tailored treatment based on biological and clinical factors.
  • Supportive care, quality of life, toxicity management, and clinical trial participation are crucial components of care.