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Related Experiment Video

Updated: Jul 12, 2026

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
04:45

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way

Published on: May 10, 2021

Resection Outcomes According to Pathologic Risk in ≤2 cm Invasive Lung Adenocarcinoma.

Zhizhou Yang1, Daniel X Xiong2, Erin Y Yuan2

  • 1Department of Surgery, Division of Thoracic Surgery, Mass General Brigham, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.

The Journal of Thoracic and Cardiovascular Surgery
|July 9, 2026
PubMed
Summary

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This summary is machine-generated.

For small lung adenocarcinomas, resection extent matters more for high-risk tumors. While low-risk tumors have similar outcomes across resection types, high-risk tumors show worse recurrence-free survival with less extensive surgery.

Area of Science:

  • Thoracic Surgery
  • Surgical Oncology
  • Pulmonary Medicine

Background:

  • Lung adenocarcinoma invasiveness and biologic risk influence treatment decisions.
  • Determining the oncologic adequacy of different resection types is crucial for optimizing patient outcomes.

Purpose of the Study:

  • To investigate if the oncologic adequacy of lung adenocarcinoma resection varies based on biologic risk.
  • To compare locoregional recurrence (LR), overall survival (OS), and recurrence-free survival (RFS) across lobectomy, segmentectomy, and wedge resection for small, node-negative tumors.

Main Methods:

  • Retrospective analysis of 1,436 patients with pathologic node-negative lung adenocarcinoma (invasive size ≤2 cm) from 2010-2022.
  • Tumor risk stratification into low, high, and very high based on adverse pathologic features (spread through air spaces, lymphovascular invasion, visceral pleural invasion, high-grade histology).
Keywords:
lung adenocarcinomapathologic risksublobar resection

Related Experiment Videos

Last Updated: Jul 12, 2026

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
04:45

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way

Published on: May 10, 2021

  • Evaluation of LR using competing-risk cumulative incidence and Fine-Gray models; OS and RFS assessed with overlap-weighted Cox models.

    • Main Results:

    • Locoregional recurrence (LR) remained low across resection types for low-risk tumors.
    • High-risk tumors showed increased LR with lesser resection extent (wedge resection > segmentectomy > lobectomy).
    • Wedge resection was associated with higher LR and worse RFS in high-risk cohorts; lobectomy favored OS and RFS overall.

    Conclusions:

    • Resection extent's oncologic adequacy for small, node-negative lung adenocarcinomas is dependent on tumor biology.
    • Low-risk tumors tolerate various resection types with low recurrence, while high-risk tumors necessitate more extensive resection for better outcomes.