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Related Experiment Video

Updated: Jul 12, 2026

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

Redox-responsive LNPs for therapeutics delivery.

You Zhou¹, Nan Lu², Hasan Muhammad Waqqas¹

¹The NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, University of Guangzhou Medical University, Guangzhou 511436, PR China.

Advanced Drug Delivery Reviews

|July 9, 2026

Summary

Redox-responsive lipid nanoparticles exploit disease redox imbalances for controlled drug release, enhancing gene therapies and theranostics. These advanced nanomedicines show promise for various diseases but face challenges in translation.

Keywords:

Gene/drug delivery LNPs Redox responsiveness

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Area of Science:

Nanomedicine
Biotechnology
Drug Delivery

Background:

Disease-specific redox imbalances (e.g., high glutathione, ROS) are key targets.
Controlled cargo release from nanocarriers is crucial for therapeutic efficacy.
Lipid nanoparticles (LNPs) offer a versatile platform for various therapeutic payloads.

Purpose of the Study:

To review the biological basis and design principles of redox-responsive LNPs.
To summarize advances in payload delivery and targeting using these nanocarriers.
To critically discuss challenges and future directions for LNP-based therapeutics.

Main Methods:

Literature review of redox-responsive LNP strategies.
Analysis of LNP design principles for controlled release.
Discussion of current bottlenecks and future research avenues.

Main Results:

Redox-responsive LNPs enable triggered release and structural activation.
These nanoparticles are effective for delivering nucleic acids, small molecules, proteins, and theranostics.
Significant progress has been made in payload delivery and targeting capabilities.

Conclusions:

Redox-responsive LNPs are a promising platform for precision nanomedicine, particularly for gene therapy.
Challenges such as redox heterogeneity, stability, and translational complexity need to be addressed.
Future research should focus on organ-selective delivery, theranostics, and clinical translation.