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Measurement of Ovarian Reserve to Tailor Systemic Therapy Decisions: Future Potential or Ready for Primetime?

C Valenza1, A H Partridge1

  • 1Harvard Medical School, Boston, MA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

Annals of Oncology : Official Journal of the European Society for Medical Oncology
|July 9, 2026
PubMed
Abstract

No abstract available in PubMed .

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Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...

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