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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...

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Updated: Jul 12, 2026

Basophil Activation Test for Allergy Diagnosis
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Published on: May 31, 2021

Timing of Food Introduction and Allergy Prevention: An Update.

Ami Shah1, Scott H Sicherer1, Angela Tsuang1

  • 1Division of Allergy and Immunology, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA.

Immunology and Allergy Clinics of North America
|July 9, 2026
PubMed
Summary

Updated infant feeding guidelines emphasize early introduction of allergenic foods like peanut and egg. Maternal and infant diet diversity may also reduce allergy risk, while skin emollients show no proven benefit for food allergy prevention.

Keywords:
Atopic dermatitisAtopyDiet diversityEarly introductionFood allergyPrevention

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Area of Science:

  • Immunology
  • Pediatrics
  • Nutrition Science

Background:

  • Dietary recommendations for infant allergy prevention are evolving rapidly based on new research.
  • Recent studies and meta-analyses inform updated guidance on infant feeding practices.
  • The role of maternal and infant diet diversity in allergy prevention is an emerging area of investigation.

Purpose of the Study:

  • To summarize current recommendations for infant allergy prevention through diet.
  • To highlight the impact of recent studies on infant feeding guidance.
  • To evaluate the evidence for early introduction of allergenic foods and diet diversity.

Main Methods:

  • Review of recent studies and meta-analyses on infant feeding and allergy prevention.
  • Analysis of updated guidance from multiple health organizations.
  • Assessment of evidence regarding specific foods (peanut, egg) and dietary diversity.

Main Results:

  • Growing evidence supports the early introduction of allergenic foods, particularly peanut and egg.
  • Infant and maternal diet diversity shows potential in reducing the risk of food allergy and atopy.
  • Skin emollients have not demonstrated efficacy in preventing food allergy.

Conclusions:

  • Current evidence favors early introduction of allergenic foods for allergy prevention.
  • Promoting diverse maternal and infant diets may be a key strategy for reducing allergy risk.
  • Further research is needed to clarify the role of emollients in atopic dermatitis prevention.