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Impact of Adjuvant Radiotherapy on Recurrence Outcomes in pT2N0 Oral Squamous Cell Carcinoma: A Propensity
Hemant Nemade1, Abhinav Thaduri1, Jonathan T Gondi1
1Department of Head and Neck Oncology, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, India.
Background:
The benefit of adjuvant radiotherapy in pT2N0 oral squamous cell carcinoma (OSCC) remains uncertain. We evaluated its impact on disease-free survival (DFS) using propensity score matching.
Methods:
Patients with pT2N0 OSCC treated between 2015 and 2023 were identified from a prospectively maintained database. One-to-one nearest-neighbor propensity score matching was performed using age, tumor size, depth of invasion, perineural invasion, lymphovascular invasion, margin distance, tumor subsite, histological grade, and bilateral neck dissection status. Three-year DFS was analyzed using Kaplan-Meier methods and Cox regression.
Results:
Among 400 eligible patients, 226 underwent surgery alone, and 174 received adjuvant radiotherapy. Propensity score matching generated 107 matched pairs. Three-year DFS was 78.3% for surgery alone and 82.1% for surgery plus radiotherapy (p = 0.41). Adjuvant radiotherapy was not associated with improved DFS (HR 0.81, 95% CI 0.48-1.30; p = 0.43).
Conclusions:
In this propensity score-matched cohort, adjuvant radiotherapy was not associated with improved 3-year DFS in pT2N0 OSCC.
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