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Updated: Jul 12, 2026

Pancreatic Islet Embedding for Paraffin Sections

Pancreatic Islet Embedding for Paraffin Sections

Published on: June 29, 2018

Islet ultrastructure: past achievements and future directions.

Andreas Müller^1,2,3, Solange Aurrecoechea Duran^4,5,6, Patrícia I Santos^4,5,6

¹Molecular Diabetology, University Hospital and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany. andreas.mueller1@tu-dresden.de.

|July 9, 2026

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Islets of Langerhans, crucial for glucose control, have been studied using advanced microscopy. Understanding islet cell ultrastructure aids in comprehending diabetes and improving treatments.

Area of Science:

Endocrinology
Cell Biology
Diabetes Research

Background:

Islets of Langerhans regulate glucose homeostasis via hormones like insulin.
Beta cell dysfunction is central to diabetes mellitus.
Microscopy has been vital for studying islet cell structure and function.

Purpose of the Study:

To review the evolution of islet imaging techniques.
To highlight contributions of electron microscopy to understanding islet cell biology.
To discuss current advancements and future directions in islet imaging.

Main Methods:

Review of historical and recent microscopy studies on pancreatic islets.
Analysis of electron microscopy data for ultrastructural details.
Discussion of 2D and 3D imaging advancements.

Keywords:

Electron microscopy Islets of Langerhans Review Ultrastructure

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A Simple High Efficiency Protocol for Pancreatic Islet Isolation from Mice

A Simple High Efficiency Protocol for Pancreatic Islet Isolation from Mice

Published on: August 30, 2019

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Last Updated: Jul 12, 2026

Pancreatic Islet Embedding for Paraffin Sections

Pancreatic Islet Embedding for Paraffin Sections

Published on: June 29, 2018

A Simple High Efficiency Protocol for Pancreatic Islet Isolation from Mice

A Simple High Efficiency Protocol for Pancreatic Islet Isolation from Mice

Published on: August 30, 2019

Main Results:

Electron microscopy has provided key insights into islet cell ultrastructure and protein trafficking.
Recent advances enable nanoscale imaging within the tissue context.
3D imaging offers a more comprehensive view of islet architecture.

Conclusions:

Continued advancements in imaging are essential for understanding islet cell function and dysfunction.
Integrating diverse imaging modalities can enhance structural insights.
Improved structural understanding may lead to better diabetes therapies.