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Related Experiment Video

Updated: Jul 12, 2026

Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence

Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence

Published on: August 14, 2019

Detection and Separation of Circulating Tumor Cells Using Magnetic Fluorescent Nanoparticles.

Shuiling Chen^1,2, Yuwei Zhou^1,2, Shaobing Zhou^1,2

¹Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, China.

Methods in Molecular Biology (Clifton, N.J.)

|July 9, 2026

Summary

Researchers developed novel magnetic nanoparticles for improved circulating tumor cell (CTC) capture and analysis in liquid biopsies. This innovation enhances early cancer detection and monitoring by preserving cell integrity.

Keywords:

Broad-spectrum capture Circulating tumor cells In situ labeling Magnetic nanoparticles Stimuli-responsiveness

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Capture and Release of Viable Circulating Tumor Cells from Blood

Capture and Release of Viable Circulating Tumor Cells from Blood

Published on: October 28, 2016

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Last Updated: Jul 12, 2026

Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence

Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence

Published on: August 14, 2019

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Published on: November 14, 2025

Capture and Release of Viable Circulating Tumor Cells from Blood

Capture and Release of Viable Circulating Tumor Cells from Blood

Published on: October 28, 2016

Area of Science:

Biomedical Engineering
Nanotechnology
Oncology

Background:

Circulating tumor cells (CTCs) are vital biomarkers for cancer diagnosis, monitoring, and prognosis.
Current immunomagnetic separation methods for CTCs have limitations, including low capture efficiency and potential cell damage.
There is a need for advanced techniques to improve CTC isolation and viability for reliable liquid biopsy analysis.

Purpose of the Study:

To develop a novel nanoplatform for efficient and non-destructive isolation and labeling of circulating tumor cells (CTCs).
To overcome the limitations of existing immunomagnetic separation methods for CTCs.
To enhance the clinical utility of CTC-based liquid biopsy.

Main Methods:

Fabrication of core-shell magnetic fluorescent nanoparticles (FR@Z-pTA NPs) with an Fe3O4 core, ZIF-8 shell, and tannic acid coating.
Utilizing the nanoparticles for broad-spectrum, high-efficiency capture of diverse CTCs.
Implementing in situ fluorescent labeling and stimuli-responsive (pH and ATP) mild cell release.

Main Results:

The FR@Z-pTA NPs demonstrated high-efficiency capture of various CTCs.
The nanoparticles enabled in situ fluorescent labeling of captured CTCs.
A mild, non-destructive cell release mechanism was achieved, preserving cell viability.
The nanoplatform showed responsiveness to pH and ATP stimuli for controlled release.

Conclusions:

The developed FR@Z-pTA NPs offer a promising solution for improved CTC isolation in liquid biopsies.
This novel nanoplatform enhances CTC capture efficiency and preserves cell viability for downstream analysis.
The technology has the potential to advance the clinical application of CTC-based liquid biopsy for cancer management.