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Highly Efficient Capture of Sarcoma Cells in Microfluidic Devices.

Yang Zhang¹, Joanne P Lagmay², Z Hugh Fan³

¹Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL, 32611, USA.

Methods in Molecular Biology (Clifton, N.J.)

|July 9, 2026

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Microfluidics-Enabled Isolation and Single-Cell Analysis of Circulating Tumor Cells.

Methods in molecular biology (Clifton, N.J.)·2023

Circulating tumor cells (CTCs) are rare but crucial cancer biomarkers. Lateral filter array microfluidic (LFAM) devices offer a sensitive method for enumerating these rare cells in sarcoma patient blood samples.

Area of Science:

Biomedical Engineering
Oncology
Microfluidics

Background:

Circulating tumor cells (CTCs) are vital biomarkers for cancer management and prognosis.
The clinical use of CTCs is hindered by their low abundance and heterogeneity in blood.
Microfluidic technology provides a sensitive and specific platform for CTC isolation and analysis.

Purpose of the Study:

To detail the fabrication of lateral filter array microfluidic (LFAM) devices.
To describe methods for capturing and detecting sarcoma CTCs using LFAM devices.
To highlight the clinical potential of LFAM devices for CTC enumeration.

Main Methods:

Fabrication of lateral filter array microfluidic (LFAM) devices.
Application of LFAM devices for the enumeration of CTCs in sarcoma patient blood.

Keywords:

Circulating tumor cells Lateral filter array Microfabrication Microfluidics Sarcoma

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Techniques for CTC capture and detection using microfluidic platforms.

Main Results:

LFAM devices were successfully fabricated.
Sarcoma CTCs were enumerated using the developed LFAM devices.
The study demonstrates the feasibility of using LFAM for CTC analysis.

Conclusions:

LFAM devices are effective for enumerating rare circulating tumor cells.
This microfluidic approach shows promise for clinical applications in cancer diagnostics and monitoring.
Further research can optimize LFAM devices for broader clinical utility in oncology.