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Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...

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Androgen Receptor Variant 7 (AR-V7) Protein Detection in Circulating Tumor Cells by Immunocytostaining.

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Related Experiment Video

Updated: Jul 12, 2026

Serum and Plasma Copy Number Detection Using Real-time PCR
09:21

Serum and Plasma Copy Number Detection Using Real-time PCR

Published on: December 15, 2017

Androgen Receptor Variant 7 (AR-V7) Transcript Expression in Circulating Tumor Cells.

Tanzila Khan1,2, Yafeng Ma3,4, Alison Luk5

  • 1Ingham Institute Applied and Medical Research, Liverpool, NSW, Australia. tanzila.khan@inghaminstitute.org.au.

Methods in Molecular Biology (Clifton, N.J.)
|July 9, 2026
PubMed
Summary

Detecting androgen receptor variant 7 (AR-V7) in circulating tumor cells (CTCs) using droplet digital PCR (ddPCR) offers a practical approach for monitoring prostate cancer progression and treatment resistance.

Keywords:
Androgen receptor variant 7 (AR-V7)Circulating tumor cell (CTC)Droplet digital PCR (ddPCR)Prostate cancerandrogen receptor (AR)

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Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

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Last Updated: Jul 12, 2026

Serum and Plasma Copy Number Detection Using Real-time PCR
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Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Prostate cancer research increasingly focuses on targeted therapies.
  • Liquid biopsies offer a practical alternative to tissue sampling for cancer monitoring.
  • Androgen receptor variant 7 (AR-V7) is linked to castrate-resistant prostate cancer (CRPC) and treatment resistance.

Purpose of the Study:

  • To develop and describe a sensitive method for detecting AR-V7.
  • To enable longitudinal monitoring of prostate cancer evolution.
  • To facilitate the study of AR-V7 in circulating tumor cells (CTCs).

Main Methods:

  • Utilized droplet digital PCR (ddPCR) for high-sensitivity detection.
  • Focused on the detection of AR-V7 expression.
  • Employed circulating tumor cells (CTCs) as the biological sample.

Main Results:

  • Successfully established a ddPCR method for AR-V7 detection in CTCs.
  • Demonstrated the feasibility of using liquid biopsies for AR-V7 analysis.
  • Provided a sensitive tool for prostate cancer biomarker detection.

Conclusions:

  • Droplet digital PCR (ddPCR) is a highly sensitive method for detecting AR-V7 in CTCs.
  • This method supports non-invasive, longitudinal monitoring of prostate cancer.
  • AR-V7 detection in CTCs can aid in managing CRPC and guiding treatment strategies.