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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Liquid Biopsies and Molecular Imaging for Precise Cancer Management.

Angelo Castello1, Matteo Caracciolo2, Mirco Bartolomei2

  • 1Nuclear Medicine Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.

Methods in Molecular Biology (Clifton, N.J.)
|July 9, 2026
PubMed
Summary
This summary is machine-generated.

Combining liquid biopsies and positron emission tomography (PET) imaging offers a powerful approach to enhance cancer detection and management. This integration aims to improve cancer characterization, patient stratification, and early recurrence detection.

Keywords:
Cell-free nucleic acidsCirculating tumor DNACirculating tumor cellsLiquid biopsyPET/CTPositron emission tomographyPrognosisResponse to treatment

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Area of Science:

  • Oncology
  • Molecular Diagnostics
  • Medical Imaging

Background:

  • Liquid biopsies detect tumor molecular alterations (e.g., circulating tumor DNA, circulating tumor cells) for cancer insights.
  • Current liquid biopsy biomarkers show limitations in sensitivity and specificity when used independently.
  • Positron emission tomography (PET) is widely used in cancer patient management.

Purpose of the Study:

  • To explore the synergistic potential of combining liquid biopsy with PET imaging in oncology.
  • To review studies integrating liquid biopsy and PET parameters across various cancer types and treatments.
  • To assess the combined approach for improved cancer characterization, patient stratification, and early recurrence detection.

Main Methods:

  • Review of studies combining liquid biopsy techniques (ctDNA, CTCs, exosomes) with PET imaging.
  • Analysis of data across diverse cancer types and therapeutic interventions.
  • Focus on the diagnostic and prognostic value of combined biomarkers and imaging.

Main Results:

  • Combination of liquid biopsy and PET shows promise for enhanced cancer detection and characterization.
  • Integrated approaches may overcome the limitations of individual biomarker sensitivities.
  • Evidence suggests improved patient stratification and early identification of disease recurrence.

Conclusions:

  • The integration of liquid biopsy and PET imaging represents a significant advancement in oncological diagnostics.
  • Combined strategies offer a more comprehensive understanding of tumor biology and patient status.
  • Further research is warranted to fully realize the clinical utility of this multimodal approach.