Related Experiment Video
Updated: Jul 12, 2026
08:12
Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
Published on: March 14, 2019
Anti-Human Epidermal Growth Factor Receptor 2 therapies in metastatic colorectal cancer: a systematic review and
Simone Rota1, Paola Di Nardo1, Emma Zottarelli1
1Department of Medical Oncology, CRO di Aviano-National Cancer Institute, IRCCS, Aviano, 33081, Italy.
The Oncologist
|July 9, 2026
Summary
Anti-HER2 treatments (HER2Tx) show efficacy in metastatic colorectal cancer (mCRC) patients with HER2 amplification. Trastuzumab deruxtecan (T-DXd) and trastuzumab-tucatinib (T-Tu) demonstrated superior response rates compared to trastuzumab-pertuzumab (T+P).
Area of Science:
- Oncology
- Translational Research
- Clinical Trials
Background:
- HER2 amplification is linked to poor prognosis and resistance to anti-EGFR therapy in colorectal cancer.
- Identifying effective treatments for HER2-amplified metastatic colorectal cancer (mCRC) is crucial.
Purpose of the Study:
- To systematically review and meta-analyze data on anti-HER2 treatments (HER2Tx) in HER2-overexpressed mCRC.
- To evaluate the efficacy of different HER2Tx regimens in pretreated mCRC patients.
Main Methods:
- Systematic literature search of phase II/III clinical trials (CTs) involving HER2Tx in HER2-overexpressed mCRC.
- Exclusion of CTs combining HER2Tx with chemotherapy.
- Pooled analysis of objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), and overall survival (OS).
Main Results:
- Analysis of 10 CTs involving 467 patients treated with various HER2Tx regimens.
- Pooled ORR was 33.7% and pooled DCR was 68.5%.
- Trastuzumab deruxtecan (T-DXd) and trastuzumab-tucatinib (T-Tu) showed higher ORR and DCR compared to trastuzumab-pertuzumab (T+P).
Conclusions:
- Anti-HER2 treatments (HER2Tx) are effective in pretreated mCRC patients, showing good DCR and ORR with promising PFS and OS.
- T-DXd and T-Tu may offer superior efficacy over T+P in HER2-amplified mCRC.
- Further research is warranted to confirm these findings.
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