Related Experiment Video

Updated: Jul 12, 2026

Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery (ALCAPA)
13:10

Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery (ALCAPA)

Published on: April 24, 2017

National Mortality Trends Associated with Anomalous Aortic Origin of Coronary Artery in the United States: A CDC

Ahmed Kamal Siddiqi1, Kumail Mustafa Ali2, Syeda Ilsa Aaqil2

  • 1From the Division of Cardiothoracic Imaging, Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA.

Cardiology in Review
|July 10, 2026
PubMed

Insights

Anomalous aortic origin of a coronary artery (AAOCA) mortality declined overall but remains high in men and Black individuals. Recent increases highlight the need for early detection and intervention for this rare congenital heart defect.

Area of Science:

  • Cardiovascular Medicine
  • Congenital Heart Disease Epidemiology
  • Public Health Surveillance

Background:

  • Anomalous aortic origin of a coronary artery (AAOCA) is a rare congenital anomaly with limited mortality data.
  • Understanding AAOCA-related mortality trends and disparities is crucial for public health initiatives.

Purpose of the Study:

  • To characterize temporal trends and demographic disparities in AAOCA-related mortality in the United States from 1999 to 2023.
  • To identify specific populations disproportionately affected by AAOCA mortality.

Main Methods:

  • Utilized the CDC Wide-Ranging Online Data for Epidemiologic Research (WONDER) database for multiple-cause-of-death data.
  • Analyzed age-adjusted mortality rates (AAMR) stratified by year, sex, race, region, and urbanization.
  • Employed Joinpoint regression to compute annual percent changes in mortality rates.

Main Results:

  • Overall AAOCA mortality showed a significant decline by 2020, followed by a recent increase.
  • Males consistently exhibited higher AAMRs than females.
  • Non-Hispanic Blacks had the highest AAMRs, followed by Non-Hispanic Whites and Hispanics.
  • Mortality declined in younger age groups (<44 years) but plateaued in older adults (>45 years).

Conclusions:

  • Despite an overall decline, AAOCA mortality remains a concern, particularly for men, Non-Hispanic Blacks, and residents of the Midwest.
  • The recent rebound in mortality emphasizes the critical need for enhanced early detection, risk stratification, and surveillance strategies.
  • Timely interventions are essential to mitigate the impact of AAOCA on public health.

Keywords:
Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Researchanomalous aortic origin of a coronary arterymortalitytrends

More Related Videos

Modified Octopus Technique for Thoracoabdominal Aortic Aneurysm04:56

Modified Octopus Technique for Thoracoabdominal Aortic Aneurysm

Published on: August 1, 2025

Related Concept Videos

Aneurysm I: Introduction01:30

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
Thoracic Aorta01:15

Thoracic Aorta

The thoracic section of the aorta begins at the T5 vertebra and extends to the T12 level at the diaphragm, initially progressing through the mediastinum to the left of the spinal column. Throughout its course in the thoracic segment, the thoracic aorta emits various offshoots known collectively as visceral and parietal branches. The branches that predominantly supply blood to visceral organs are termed visceral branches and include bronchial, pericardial, esophageal, and mediastinal arteries,...