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![[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Copper-Catalyzed Difluoromethylborylation of Unactivated Alkenes Enabled by an NMP Stabilized ICF2H Reagent
Chenyang Liu1, Lili Zhao1, Jiaming Li1
1School of Chemistry and Chemical Engineering, Nanchang University, Nanchang, Jiangxi 330031, China.
Abstract:
We herein describe a copper-catalyzed difunctionalization of unactivated alkenes that enables the simultaneous installation of difluoromethyl and boron-containing groups under mild conditions with excellent chemoselectivity. This strategy combines the favorable pharmaceutical properties of the difluoromethyl group with the versatile derivatization potential of the organoboron unit, thereby providing an efficient and modular approach to structurally diverse and potentially bioactive difluoromethylated molecules.
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