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Related Concept Videos

Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Related Experiment Videos

Crosstalk Between Immunometabolic Pathways in Non-Small Cell Lung Cancer.

Riya Khilwani1, Pooja Gulhane1, Manasi Tukrul1,2

  • 1Biotechnology Research and Innovation Council-National Centre for Cell Science (BRIC-NCCS), Savitribai Phule Pune University Campus, Pune, India.

Immunological Investigations
|July 10, 2026
PubMed
Summary

Inflammatory cytokines like IL-6 and IL-17 reprogram immune cell metabolism in non-small cell lung cancer (NSCLC), promoting tumor growth and immune evasion. Understanding these immunometabolic networks could lead to new precision oncology therapies.

Keywords:
IL-6/17ImmunometabolismNSCLCautophagyinflammationproteinssignaling pathways

Related Experiment Videos

Area of Science:

  • Immunology
  • Oncology
  • Metabolism

Background:

  • Immunometabolic reprogramming is crucial for immune responses and tumor progression in non-small cell lung cancer (NSCLC).
  • Tumor microenvironment alterations by immunometabolism facilitate immune evasion in NSCLC.
  • The interplay between inflammatory cytokines, metabolic signaling, and autophagy in NSCLC is not well understood.

Purpose of the Study:

  • To review the roles of Interleukin-6 (IL-6) and Interleukin-17 (IL-17) in inflammaphagy and immunometabolic networks.
  • To highlight conserved regulatory pathways (BMP, DUSP, FOXO, SPROUTY, STING) in immune cell metabolism and tumor progression.

Main Methods:

  • A narrative review of recent experimental and clinical literature.
  • Integration of findings to establish a framework for cytokine interactions, immune metabolism, and tumor progression.

Main Results:

  • IL-6 and IL-17 critically regulate tumor cell metabolism and influence immune cells (macrophages, T-cells, neutrophils) towards metabolic shifts.
  • Conserved pathways (BMP, DUSP, FOXO, SPROUTY, STING) modulate metabolic homeostasis and crosstalk between inflammatory and metabolic networks.

Conclusions:

  • Understanding the links between inflammatory cytokines, autophagy, and metabolism can reveal novel therapeutic targets.
  • This knowledge may enhance immunotherapy effectiveness for precision oncology in NSCLC.