Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Simplified Synchronous Machine Model01:30

Simplified Synchronous Machine Model

The Synchronous Machine Model is a fundamental tool in analyzing and ensuring the transient stability of power systems. This model simplifies the representation of a synchronous machine under balanced three-phase positive-sequence conditions, assuming constant excitation and ignoring losses and saturation. The model is pivotal for understanding the behavior of synchronous generators connected to a power grid, particularly during transient events.
In this model, each generator is connected to a...
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
Fast Decoupled and DC Powerflow01:24

Fast Decoupled and DC Powerflow

The fast decoupled power flow method addresses contingencies in power system operations, such as generator outages or transmission line failures. This method provides quick power flow solutions, essential for real-time system adjustments. Fast decoupled power flow algorithms simplify the Jacobian matrix by neglecting certain elements, leading to two sets of decoupled equations:
Extraction: Partition and Distribution Coefficients01:14

Extraction: Partition and Distribution Coefficients

The distribution law or Nernst's distribution law is the law that governs the distribution of a solute between two immiscible solvents. This law, also known as the partition law, states that if a solute is added to the mixture of two immiscible solvents at a constant temperature, the solute is distributed between the two solvents in such a way that the ratio of solute concentrations in the solvents remains constant at equilibrium.
For extracting a solute from an aqueous phase into an organic...
Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least squares (OLS)...
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An annotated, chromosome-level genome for the spotted turtle, Clemmys guttata.

The Journal of heredity·2026
Same author

WITHDRAWN: GhostHunter: A Multi-Test Framework for Detecting Ghost Introgression.

bioRxiv : the preprint server for biology·2026
Same author

The missing data problem in population genomics and statistical methods to address them.

G3 (Bethesda, Md.)·2026
Same author

<i>SaVor</i> - A Reproducible Structural Variant Calling and Benchmarking Platform from Short-Read Data.

bioRxiv : the preprint server for biology·2025
Same author

A COMPREHENSIVE CATALOG OF TELOMERE CONTENT VARIATION ACROSS HUMAN POPULATIONS.

bioRxiv : the preprint server for biology·2025
Same author

A novel machine learning approach for tumor detection based on telomeric signatures.

Biology methods & protocols·2025

Related Experiment Video

Updated: Jul 12, 2026

A Uniaxial Compression Experiment with CO2-Bearing Coal Using a Visualized and Constant-Volume Gas-Solid Coupling Test System
10:27

A Uniaxial Compression Experiment with CO2-Bearing Coal Using a Visualized and Constant-Volume Gas-Solid Coupling Test System

Published on: June 12, 2019

CoalMiner: a coalescent model generator for fastsimcoal2.

Raya Esplin-Stout, Arun Sethuraman

    Biorxiv : the Preprint Server for Biology
    |July 10, 2026
    PubMed
    Summary

    CoalMiner is a new Python tool that generates demographic models for population genetics. It helps researchers explore complex evolutionary histories more effectively using the Site Frequency Spectrum (SFS).

    Area of Science:

    • Population Genetics
    • Evolutionary Biology
    • Computational Biology

    Background:

    • Demographic inference using the Site Frequency Spectrum (SFS) is limited by the number and complexity of models.
    • Exploring diverse demographic histories is crucial for understanding evolutionary processes.

    Purpose of the Study:

    • To introduce CoalMiner, a novel coalescent model generator for fastsimcoal2.
    • To facilitate the generation of biologically plausible demographic models for population genetic analyses.

    Main Methods:

    • CoalMiner employs a decision tree framework to generate demographic models.
    • User input defines demographic parameters and histories for model generation.
    • Generated models are compatible with the fastsimcoal2 pipeline.

    More Related Videos

    Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0
    07:41

    Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0

    Published on: June 5, 2017

    Related Experiment Videos

    Last Updated: Jul 12, 2026

    A Uniaxial Compression Experiment with CO2-Bearing Coal Using a Visualized and Constant-Volume Gas-Solid Coupling Test System
    10:27

    A Uniaxial Compression Experiment with CO2-Bearing Coal Using a Visualized and Constant-Volume Gas-Solid Coupling Test System

    Published on: June 12, 2019

    Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0
    07:41

    Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0

    Published on: June 5, 2017

    Main Results:

    • CoalMiner effectively expands the exploration of demographic model space.
    • Simulations and empirical data demonstrate CoalMiner's utility as a helper tool.
    • The tool enhances the process of demographic inference.

    Conclusions:

    • CoalMiner is an effective tool for generating and exploring demographic models in population genetics.
    • The Python-based generator is freely available with tutorials for ease of use.