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Updated: Jul 12, 2026

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection
09:15

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection

Published on: February 28, 2019

Antibody Correlates of Resilience to Staphylococcus aureus Disease and Recurrence in Children

Mehak Zahoor Khan, Carol M Kao, Wonyeong Jung

    Biorxiv : the Preprint Server for Biology
    |July 10, 2026
    PubMed

    Insights

    Understanding Staphylococcus aureus immunity is crucial for developing vaccines. This study identifies key antibody targets and functions associated with protection against S. aureus infections and carriage in children.

    Area of Science:

    • Immunology
    • Microbiology
    • Infectious Diseases

    Background:

    • Staphylococcus aureus is a significant pathogen with no available vaccine, leading to frequent infections.
    • Correlates of protection against S. aureus are not well-defined, hindering vaccine development.

    Purpose of the Study:

    • To comprehensively profile immune responses in children with varying S. aureus colonization and infection statuses.
    • To identify antibody features associated with protection against S. aureus skin and soft tissue infections (SSTI) and invasive disease.

    Main Methods:

    • Prospective cohort study of 319 children.
    • Extensive antibody profiling of 182,149 features.
    • Multivariate modeling to distinguish clinical phenotypes and identify protective antigens.

    Main Results:

    • Antibody responses and Fc-receptor engagement increase with age.
    • Asymptomatic carriage is linked to functional antibodies targeting conserved antigens and toxins.
    • Specific antibody profiles and enhanced FcγR binding correlate with protection against recurrent S. aureus disease.

    Conclusions:

    • Key antigen targets for S. aureus vaccines and therapeutics have been identified.
    • Anti-Hla neutralizing antibodies and functional antibodies to surface antigens are important for protection.
    • Findings inform the development of next-generation vaccines and monoclonal antibody strategies.

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