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Published on: August 1, 2018

Isolated Nocturnal Hypertension and Target Organ Damage: A SHIP-AHOY Ancillary Study

Taylor Hill-Horowitz1, Meredith Akerman, Michael Ferguson2

  • 1Albert Einstein College of Medicine.

Research Square
|July 10, 2026
PubMed

Insights

Isolated nocturnal hypertension (INH) is common in adolescents and significantly increases the risk of left ventricular hypertrophy (LVH). Further research is needed to understand the long-term effects of INH in pediatric populations.

Area of Science:

  • Pediatric Cardiology
  • Hypertension Research
  • Cardiovascular Epidemiology

Background:

  • Isolated nocturnal hypertension (INH) and its link to target organ damage (TOD) are understudied in pediatric populations.
  • The Study of Hypertension in Pediatrics, Adult Hypertension Onset in Youth (SHIP-AHOY) cohort provides data to investigate INH prevalence and TOD.
  • INH is hypothesized to correlate with an elevated risk of TOD in adolescents.

Purpose of the Study:

  • To determine the prevalence of INH in the SHIP-AHOY cohort.
  • To investigate the association between INH and target organ damage, specifically left ventricular hypertrophy (LVH).
  • To evaluate the risk of TOD associated with INH in adolescents.

Main Methods:

  • Utilized data from the SHIP-AHOY cohort.
  • Defined primary exposure, INH, using static thresholds (wake < 130/80, sleep ≥ 110/65) and 95th percentile ambulatory BP.
  • Assessed primary outcome, left ventricular hypertrophy (LVH), via left ventricular mass index (> 38.6 g/m2.7) and employed logistic regression for analysis.

Main Results:

  • INH was identified in 19.7% of adolescents using static thresholds, primarily due to systolic BP.
  • Adolescents with INH exhibited higher age and height, and lower estimated glomerular filtration rate compared to normotensive individuals.
  • A significant association was found between INH and LVH, with a 2.7-fold increased adjusted odds (95% CI [1.20,5.93], P = 0.016).

Conclusions:

  • Isolated nocturnal hypertension (INH) is prevalent among adolescents and is linked to a 2.7-fold higher risk of left ventricular hypertrophy (LVH).
  • Findings highlight the importance of monitoring nocturnal blood pressure in pediatric hypertension.
  • Longitudinal studies are recommended to fully understand the long-term consequences of INH in youth.
Abstract

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