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Updated: Jul 12, 2026
06:46
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
Association between SARS-CoV-2 and diabetes: A population-based cohort study using the UK CPRD GOLD database
P Spivakovsky1, N L Barclay1,2, E Burn1
1Botnar Research Centre, Centre for Statistics in Medicine (CSM), NDORMS, University of Oxford, Old Rd, Headington, Oxford, OX3 7LD UK.
Journal of Diabetes and Metabolic Disorders
|July 10, 2026
Summary
This study found no evidence linking SARS-CoV-2 infection to new cases of Type 1 or Type 2 diabetes. Further research is needed due to a limited number of diabetes events observed.
Area of Science:
- Endocrinology
- Infectious Diseases
- Epidemiology
Background:
- Conflicting findings exist regarding the association between SARS-CoV-2 (COVID-19) and diabetes mellitus.
- Understanding this potential link is crucial for public health management and patient care.
Purpose of the Study:
- To investigate the association between SARS-CoV-2 infection and the incidence of new-onset Type 1 diabetes.
- To determine if SARS-CoV-2 infection is associated with the incidence of new-onset Type 2 diabetes.
Main Methods:
- A population-based cohort study utilized UK Clinical Practice Research Datalink (CPRD) GOLD data from January 2021 to June 2022.
- Large-scale propensity score matching (Lasso regression) was employed to match COVID-19 patients with non-COVID controls and test-negative participants.
- Poisson regression analysis examined the relationship between COVID-19 exposure and incident Type 1/Type 2 diabetes.
Main Results:
- Analysis of 161,870 COVID-19 patients matched with controls showed no significant association with Type 1 diabetes (Risk Ratio [RR] 1.27) or Type 2 diabetes (RR 1.10).
- Sensitivity analysis matching COVID-19 patients with test-negative individuals yielded similar non-significant results for Type 1 (RR 1.13) and Type 2 diabetes (RR 1.08).
Conclusions:
- The study did not find evidence supporting an association between SARS-CoV-2 infection and the new onset of Type 1 or Type 2 diabetes.
- The conclusions are limited by a small number of diabetes events, particularly for Type 1 diabetes, warranting further investigation.
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