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Related Experiment Video

Updated: Jul 12, 2026

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Multi-modal recruitment efficiency in ScreenPlus, a large-scale consented pilot NBS program.

Megan Clarke1, Katrina Paleologos1, Nicole R Kelly1

  • 1Children's Hospital at Montefiore Einstein, Albert Einstein College of Medicine, Bronx NY.

Medrxiv : the Preprint Server for Health Sciences
|July 10, 2026
PubMed
Summary

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This summary is machine-generated.

Direct communication in newborn screening (NBS) recruitment, like the ScreenPlus pilot, yields the highest consent rates. Active, in-person recruitment achieved 65.5% consent, significantly outperforming other methods.

Area of Science:

  • Genetics and Genomics
  • Public Health
  • Neonatal Medicine

Background:

  • The ScreenPlus pilot program aims to screen 100,000 infants for rare disorders.
  • It offers a unique opportunity to evaluate newborn screening (NBS) recruitment strategies.

Purpose of the Study:

  • To analyze the effectiveness of different recruitment modes within the ScreenPlus program.
  • To identify optimal practices for recruiting participants in large-scale NBS pilot studies.

Main Methods:

  • Analysis of 47,642 recruitment profiles from May 2021 to April 2025.
  • Comparison of three recruitment strategies: Active (in-person), Hybrid (various attempts), and Independent (online).

Main Results:

  • Active recruitment (72.2% of profiles) achieved the highest consent rate (65.5%) in an average of 1.2 days.
Keywords:
ConsentPilot Newborn ScreeningRecruitment

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  • Hybrid recruitment (27.1% of profiles) had a 44.5% consent rate over 8.6 days; EMR messaging was effective.
  • Independent recruitment was used in less than 1% of profiles.

    • Conclusions:

    • Multi-modal approaches are beneficial for NBS pilot recruitment.
    • Direct parent-study team communication, particularly in Active recruitment, demonstrates the highest consent yield.
    • Non-English speakers showed higher consent rates in Active and Hybrid recruitment modes.