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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

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Using In Vitro Live-cell Imaging to Explore Chemotherapeutics Delivered by Lipid-based Nanoparticles
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Drug Delivery Systems Repurposing Taxanes as Antitumor Immune Modulators.

Sang-Hun Choi1, Soo-Hyang Chi1, Chae Yeon Han1

  • 1School of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea.

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Taxanes, used in cancer therapy, can boost antitumor immunity. Advanced drug delivery systems (DDSs) improve taxane efficacy by enhancing immune responses against tumors.

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Area of Science:

  • Oncology
  • Immunology
  • Pharmacology

Background:

  • Taxane chemotherapeutics (paclitaxel, docetaxel, cabazitaxel) are vital in cancer treatment due to their cytotoxic effects.
  • Beyond direct cytotoxicity, taxanes exhibit immunomodulatory properties influencing antitumor immunity.

Purpose of the Study:

  • To review the immunomodulatory effects of taxanes.
  • To discuss advancements in taxane drug delivery systems (DDSs) for enhanced tumor targeting and immune modulation.
  • To explore synergistic chemoimmunotherapy strategies combining taxane-based DDSs with other immunotherapeutic agents.

Main Methods:

  • Literature review focusing on taxane immunomodulation and DDSs.
  • Analysis of studies investigating taxane effects on immune processes in tumors and lymph nodes.
  • Examination of research on combined taxane-DDSs with immune checkpoint inhibitors and other immunotherapies.

Main Results:

  • Taxanes modulate both local tumor immunity and systemic immune responses.
  • Taxane DDSs improve tumor targeting and lymphatic delivery, enhancing antigen presentation and adaptive immune activation.
  • Synergistic strategies combining taxane-based DDSs with immunotherapies show promise for next-generation cancer treatment.

Conclusions:

  • Taxanes possess significant immunomodulatory potential beyond their cytotoxic effects.
  • Advanced taxane DDSs can optimize therapeutic efficacy by enhancing antitumor immunity.
  • Taxane-based chemoimmunotherapy represents a promising approach for developing novel cancer treatments.