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Published on: October 27, 2020
Examining the Role of Asef and Epidermal Growth Factor on Cell Migration and Proliferation in Triple Negative Breast
Natalie Alaniz1, Khameeka N Kitt1
1Biology Department, Saint Mary's College of California, Moraga, CA, United States.
Abstract:
Cell proliferation and migration are cellular processes essential to normal cell function; errors in these cellular processes impact the ability of a cell to maintain cellular homeostasis. The current study examines the role of Asef, a GEF for Rac1, in cell proliferation and migration in the presence or absence of EGF in a triple negative breast cancer epithelial cell line. Overexpression of Asef reduced stress fiber formation and increased cell migration and proliferation in MDA-MB-231 epithelial cells. These data indicate a role for Asef in the EGFR/Rac1 signaling cascade involved in regulating cellular behavior.
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