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Novel Application of the AGN1 Triphasic Calcium-Based Implant for a Large Simple Bone Cyst in a Child With 3-Year
Nicolas De Ridder1, Charlotte Draelants2, Jo De Schepper2
1Department of Orthopaedics and Traumatology, University Hospitals Leuven (UZ Leuven), Leuven, Belgium.
Insights
This case report details the first use of AGN1 (Ossure™) to treat a large simple bone cyst (SBC) in a child. The resorbable implant provided stability, promoted bone healing, and led to full recovery with no long-term issues.
Area of Science:
- Orthopedic surgery
- Pediatric orthopedics
- Biomaterials
Background:
- Simple bone cysts (SBCs) are benign pediatric bone lesions.
- Some SBCs require treatment due to fracture risk.
- Current treatments have variable success rates.
Introduction:
Simple bone cysts (SBCs) are benign lesions in children, typically in the proximal humerus. While many are asymptomatic, some necessitate treatment because of impending pathological fractures. Different treatment modalities exist, but no consensus on the best method has been established.
Case Report:
To the best of our knowledge, this case report describes the first reported clinical application of AGN1 (Ossure™), a CE-marked triphasic calcium-based resorbable implant, in the treatment of a large SBC.A 10-year-old girl with a history of recurrent fractures secondary to a large SBC in the right humerus underwent curettage and AGN1 implantation. The procedure provided immediate stability after implantation and promoted bone healing during the resorption phase. She experienced rapid functional recovery with full mobility in 2 weeks. Early radiographic imaging showed rapid integration at 3 months. Long-term follow-up at nearly 3 years postoperatively confirmed complete resorption of the implant with restoration of normal bone architecture, leaving only a small, asymptomatic residual cyst distally.
Conclusion:
Current treatments for SBCs, including corticosteroid injections and bone grafting, show varying success rates. AGN1, known for its osteo-enhancing properties in other clinical applications, provided immediate structural support and facilitated rapid bone regeneration with complete resolution of a large SBC in this case.AGN1 may offer a promising alternative for treating large SBCs, especially in patients at high risk of fractures. Its ability to provide early mechanical stability and promote bone regeneration warrants further clinical investigation to assess its use in select cases.
