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Related Concept Videos

Traumatic Brain Injury l: Introduction01:28

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...
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Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...

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Related Experiment Video

Updated: Jul 12, 2026

Controlled Cortical Impact Model for Traumatic Brain Injury
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Published on: August 5, 2014

Dual Impact: Coup-Contrecoup Brain Injury in a Young Cyclist-A Case Report.

Abhishek Kumar1, Shashikant Prasad1, Majid Anwer1

  • 1Department of Trauma Surgery and Critical Care, All India Institute of Medical Sciences, Patna, Bihar, India, aiims.edu.

Case Reports in Surgery
|July 10, 2026
PubMed
Summary

Coup-contrecoup brain injuries, caused by trauma, can lead to significant brain damage. This case highlights the need for vigilant monitoring and staged surgical intervention for optimal patient outcomes.

Keywords:
Glasgow coma scalecase reportcoup–contrecoup brain injurydecompressive craniectomytraumatic brain injury

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Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury
05:01

Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury

Published on: August 16, 2019

Area of Science:

  • Neurosurgery
  • Traumatic Brain Injury (TBI)
  • Neurology

Background:

  • Coup-contrecoup brain injury involves damage at the impact site and contralateral side due to intracranial pressure (ICP) and rotational forces.
  • These injuries are common in high-velocity accidents and often require staged neurosurgical intervention.

Purpose of the Study:

  • To present a case of severe coup-contrecoup brain injury in a pediatric patient.
  • To illustrate the management of evolving intracranial hematomas and contusions.

Main Methods:

  • Case report of a 14-year-old male following a road traffic accident.
  • Initial CT scan, emergency craniotomy for extradural hematoma (EDH) evacuation, and subsequent decompressive craniectomy for worsening contusion and subdural hematoma (SDH).
  • Postoperative monitoring, neuroimaging, and elective cranioplasty.

Main Results:

  • Initial EDH evacuation led to temporary improvement.
  • Neurological deterioration occurred due to contralateral lesion progression (contusion and SDH).
  • Decompressive craniectomy resolved mass effect, leading to progressive neurological recovery and good functional outcome after cranioplasty.

Conclusions:

  • Coup-contrecoup injuries are complex and linked to rotational forces and ICP gradients.
  • Contralateral lesion progression is a critical concern, necessitating close monitoring and timely, staged surgical management.
  • Effective management involves repeat neuroimaging, ICP control, and surgical interventions like decompressive craniectomy and cranioplasty.