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Frailty Assessment in an Aging Mouse Model
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Defining Frailty in Chinese-Language Biomedical Literature (2014-2024): A Decade of Conceptual Evolution.

Haodong Wei1, David Mockler2, Giulia Cavrini1,3

  • 1Discipline of Medical Gerontology, School of Medicine Trinity College Dublin Dublin Ireland.

Aging Medicine (Milton (N.S.W))
|July 10, 2026
PubMed
Summary

This review explores frailty definitions in Chinese research, finding growing international alignment but limited focus on holistic aspects. Traditional Chinese medicine offers unique balance-focused views.

Keywords:
agedcross‐cultural comparisonfrailtygeriatricsterminology as topic

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Area of Science:

  • Gerontology and Aging Research
  • Biomedical Sciences
  • Cross-Cultural Health Studies

Background:

  • Frailty is a key aging concept, indicating reduced reserve and increased stress vulnerability.
  • Western frailty definitions are well-researched, but Chinese conceptualizations are less understood.
  • Understanding diverse frailty definitions is crucial for global aging research.

Purpose of the Study:

  • To systematically review frailty definitions in Chinese biomedical literature from 2014-2024.
  • To analyze sources, conceptual emphases, and trends in Chinese frailty research.
  • To assess the alignment of Chinese frailty concepts with international frameworks.

Main Methods:

  • Systematic review of Chinese biomedical publications (2014-2024).
  • Searches conducted across major Chinese and international databases.
  • Analysis of 1804 identified articles for definitional characteristics.

Main Results:

  • Increasing convergence with international frailty frameworks, notably via expert consensus.
  • Improved terminological standardization observed in recent publications.
  • Dominance of biomedical interpretations, with underrepresentation of psychological, social, and dynamic aspects.
  • Emergence of Traditional Chinese Medicine perspectives emphasizing balance and restoration.

Conclusions:

  • Chinese frailty research shows progress in standardization and international alignment.
  • Biomedical perspectives dominate, neglecting holistic and dynamic dimensions of frailty.
  • Traditional Chinese Medicine offers distinct, valuable insights into frailty.
  • Clarifying these definitions is vital for cross-cultural comparability and culturally sensitive frailty care.