Related Experiment Video
Updated: Jul 12, 2026

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
Published on: April 22, 2015
The Microbial Factors, Trace Elements, and Important Biological Indicators in Children with Autism Spectrum Disorder:
Keli Qu1, Zhiliang Gao2, Cong Chang3
1Department of Child Healthcare, Shandong Provincial Third Hospital, Shandong University, Jinan, China.
Background:
We examined and compared microbiological variables, trace elements, and biological markers in autistic children.
Methods:
Several databases, including the Cochrane Library, PubMed, OVID, Google Scholar, and Embase, were utilized for data collection and analysis. We studied meta-analysis data and used a continuous model with fixed or random effects to get mean differences (MD) with 95% confidence intervals (CIs). Twenty-seven studies involving 2557 children from 2014 to 2024 were analyzed.
Results:
Autism spectrum disorder had significantly higher C-reactive protein (MD, 1.25; 95% CI, 0.11^ndash;2.39, P=0.03), interleukin 6 (MD: 2.80; 95%CI, 1.13-4.46, P=0.001), serotonin (MD, 111.92; 95%CI, 63.75-160.09, P<0.001), Faecalibacterium (MD, 0.48; 95%CI: 0.29-0.66, P<0.001), and Parabacteroides (MD, 0.20; 95%CI: 0.14-0.26, P<0.001), lower oxytocin (MD, -53.24; 95% CI, -73.39--33.09, P<0.001), and serum iron (MD, -5.78; 95% CI, -9.43--2.13, P=0.002) compared to control in children.
Conclusion:
Autism spectrum disorder had significantly higher C-reactive protein, interleukin-6, serotonin, Faecalibacterium, Parabacteroides, lower oxytocin, and serum iron compared to control in children. Further research studies with larger sample sizes are needed.
Related Concept Videos
Autism Spectrum Disorder
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Gut-Brain Axis
Modeling in Therapy
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in situations...
Attention-Deficit/Hyperactivity Disorder
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.
Microbiota Modulation by Antibiotics