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Updated: Jul 12, 2026

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
Published on: September 22, 2023
Microbiome and metabolome integrated analysis reveals oral microbiota alterations and associated metabolic pathways
Weiwei Zhang1,2, Ping Li1,2, Shuang Zhao1,2
1Department of Endodontics, The First Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China.
Background:
Allergic rhinitis is a globally prevalent condition characterized by an increase in incidence. This study aimed to characterize differences in supragingival plaque microbial composition between patients with allergic rhinitis and healthy controls, and to explore the differential metabolites and enriched metabolic pathways to provide reference data for subsequent in-depth investigations into the pathogenesis and potential therapeutic targets of allergic rhinitis.
Material And Methods:
We employed 16S rRNA gene high-throughput sequencing technology and untargeted metabolomics to analyze the supragingival plaque microbiota of 35 healthy individuals and 35 patients with allergic rhinitis.
Results:
At the genus level, Abiotrophia, Rothia, and Actinobacillus showed significant inter-group differences. Ten species, including Prevotella melaninogenica and Capnocytophaga sputigena, exhibited markedly differential abundances. Microbial co-occurrence network analysis revealed a simpler topological architecture in the allergic rhinitis group than that in the healthy control group. Metabolomic profiling identified 106 differentially expressed metabolites that were enriched across 13 associated metabolic pathways.
Conclusion:
Under the current inclusion criteria, this study identified significant alterations in the microbial composition of supragingival plaques in patients with allergic rhinitis. Additionally, using the current sample size, this study preliminarily characterised differential metabolites and pathways, providing initial clues for identifying therapeutic targets in allergic rhinitis.
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