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Detection of Intracellular Gene Expression in Live Cells of Murine, Human and Porcine Origin Using Fluorescence-labeled Nanoparticles
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Gold Nanoplatforms for Phenotypic Reprogramming and Closed-Loop Theranostics of Cancer Stem Cells.

Bingyan Zhu1,2,3,4, Yuling Chen1,2,3,4, Yuntao Lin1,2,3,4

  • 1Department of Oral and Maxillofacial Surgery, Stomatological Center, Peking University Shenzhen Hospital, Shenzhen, Guangdong, 518036, People's Republic of China.

International Journal of Nanomedicine
|July 10, 2026
PubMed
Summary

Engineered gold nanoplatforms offer a novel approach to cancer therapy by reprogramming cancer stem cells (CSCs) and overcoming drug resistance. This strategy targets CSCs to prevent relapse and improve treatment outcomes.

Keywords:
cancer stem cellsclosed-loop theranosticsgold nanoparticlesphenotypic reprogrammingtumor microenvironment

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Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures

Published on: December 26, 2016

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Research

Background:

  • Conventional cancer therapies like photothermal ablation often fail to eliminate cancer stem cells (CSCs), leading to therapeutic resistance and relapse.
  • Sublethal stress induced by current treatments can paradoxically enhance CSC survival and promote resistance mechanisms.

Purpose of the Study:

  • To present a framework for engineered gold nanoplatforms to reprogram CSCs, shifting from non-specific cytotoxicity to mechanism-driven therapeutic strategies.
  • To detail how nanoplatforms can overcome CSC-driven therapeutic resistance and improve cancer treatment precision.

Main Methods:

  • Utilizing stimuli-responsive gold nanoplatforms with functionalized surfaces for precise intracellular delivery, overcoming the size-permeability barrier.
  • Employing nanoplatforms to suppress cancer cell defenses by modulating morphogenic pathways and inducing mesenchymal-to-epithelial transitions.
  • Disrupting the bioenergetic basis of multidrug resistance and inducing targeted cell death via ferroptosis and metabolic blockade.

Main Results:

  • Engineered gold nanoplatforms demonstrate the ability to reprogram CSCs, enhancing treatment efficacy.
  • The nanoplatform strategy effectively disrupts CSC survival mechanisms, including multidrug resistance and intrinsic defense pathways.
  • Integration of nanoplatforms with real-time feedback enables adaptive, responsive cancer therapy, promoting tumor microenvironment remodeling and immunological responses.

Conclusions:

  • Gold nanoplatforms represent a promising adaptive system for precision cancer therapy, capable of overcoming CSC-driven relapse.
  • This approach facilitates targeted cell death and modulates the tumor microenvironment, offering a new paradigm for cancer treatment.
  • The strategy highlights the potential of nanomedicine to achieve mechanism-driven phenotypic reprogramming in cancer stem cells.