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Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Substrate-Controlled Co-MHAT Catalyzed 1,4- and 1,2-Hydropyridination of 1,3-Enynes
Ying Jiang1, Xiaoming Chen1, Yu Zhou1,2
1Key Laboratory of Glyco-drug Research of Zhejiang Province, School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China.
Abstract:
The unique structure of 1,3-enyne endows it with various reactivities in organic synthesis. In the past decades, via a radical process, great progress has been made in the 1,2- and 1,4-difunctionalization of 1,3-enynes. However, the 1,2- and 1,4-hydrofunctionalization of 1,3-enynes has been studied less. Herein, we report a reductive Co-MHAT-catalyzed 1,4- and 1,2-hydropyridination of 1,3-enynes, providing efficient access to valuable propargylpyridines and allenylpyridines from the readily available starting material. Furthermore, a wide substrate scope for 1,3-enynes, excellent functional group compatibility, and the antiproliferative activity for these novel allenylpyridines demonstrated that this method has significant application in medicinal chemistry.
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