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Updated: Jul 12, 2026

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
07:49

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Published on: July 17, 2019

A‑Raf: A serine/threonine protein kinase with important biological functions (Review)

Muhan Yang1, Mengying Chen2, Jinmei Wei3

  • 1Department of Blood Transfusion, The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University/Hunan Cancer Hospital, Changsha, Hunan 410013, P.R. China.

Molecular Medicine Reports
|July 10, 2026
PubMed

Insights

A-Raf, a key protein kinase, regulates critical cellular processes like the cell cycle, apoptosis, and metabolism. This review comprehensively summarizes A-Raf

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • A-Raf is a serine/threonine protein kinase in the RAF kinase family.
  • A-Raf plays crucial roles in physiological and pathological processes.
  • Understanding A-Raf's functional mechanisms is gaining research attention.

Purpose of the Study:

  • To systematically summarize the diverse biological functions of A-Raf.
  • To provide a comprehensive understanding of A-Raf's roles.
  • To offer a novel perspective on A-Raf's multifaceted functions.

Main Methods:

  • Literature review focusing on A-Raf's effects.
  • Analysis of A-Raf's impact on cell cycle, apoptosis, and proliferation.
  • Examination of A-Raf's influence on material transport, metabolism, development, and tumor progression.

Main Results:

  • A-Raf influences cell cycle regulation, apoptosis, and proliferation.
  • A-Raf impacts cellular material transport and metabolic processes.
  • A-Raf is involved in embryonic development, bone mass maintenance, and tumor progression.

Conclusions:

  • A comprehensive understanding of A-Raf's functions requires examining its roles in various cellular and organismal processes.
  • Further research into A-Raf's genetic variations and upstream regulation is warranted.
  • This review provides a consolidated perspective on A-Raf's significance in health and disease.
Keywords:
A‑Rafbiological functionscellular metabolismgenetic variationregulatory mechanism

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