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Related Experiment Video

Updated: Jul 12, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

A ROS-Responsive Doxorubicin-Loaded Liposomal Strategy Reduces Postablation Electrical Conduction Recovery in a

Ying Zhuge1, Liping Yang2, Yulong Ge1

  • 1Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200800, China.

ACS Applied Materials & Interfaces
|July 10, 2026
PubMed
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A novel nanoplatform effectively reduced electrical conduction recovery after radiofrequency catheter ablation (RFCA) in a canine model. This liposomal therapy enhanced ablation site injury, preventing lesion reconnection and improving long-term outcomes.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Nanomedicine

Background:

  • Radiofrequency catheter ablation (RFCA) efficacy is challenged by postablation electrical conduction recovery.
  • Developing controllable adjunctive therapies is crucial for improving RFCA outcomes.
  • Current methods lack effective strategies to prevent lesion reconnection.

Purpose of the Study:

  • To establish a large-animal model for evaluating nanoplatforms in preventing postablation conduction recovery.
  • To assess the efficacy of a doxorubicin-loaded, ROS-responsive liposome (DOX@rNP) as an adjunctive therapy for RFCA.
  • To investigate the mechanisms underlying DOX@rNP's effect on ablation site remodeling and conduction block.

Main Methods:

  • A CARTO-guided canine model of right atrial postablation conduction recovery was established.
Keywords:
CARTO systemROS-responsive liposomeapoptosis inductioncanine modelsradiofrequency catheter ablation

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Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model
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Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model

Published on: January 21, 2018

Related Experiment Videos

Last Updated: Jul 12, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model
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Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model

Published on: January 21, 2018

  • Doxorubicin (DOX)-loaded, reactive oxygen species (ROS)-responsive liposomes (DOX@rNP) were developed.
  • CARTO-based voltage mapping, pacing, and in vivo electrocardiography were used for assessment.

    • Main Results:

    • DOX@rNP achieved a 2.8-fold higher local DOX concentration at the ablation site.
    • DOX@rNP induced apoptosis, modulated the Bax/Bcl-2 pathway, and reduced fibrosis.
    • DOX@rNP maintained conduction block short-term (30 days) and long-term (180 days).
    • The electrical conduction recurrence rate was significantly lower with DOX@rNP (20.0%) compared to RFCA alone (80.0%) at 180 days.

    Conclusions:

    • A ROS-responsive liposomal strategy effectively reinforces ablation-site injury.
    • DOX@rNP suppresses lesion reconnection, maintaining long-term conduction block after RFCA.
    • This study supports the use of nanoplatforms as adjunctive therapies to improve RFCA efficacy.