Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Distribution and Correlation Analysis of Microplastic Contamination in Bottom Mud of Zhengzhou Section of the Yellow River].

Huan jing ke xue= Huanjing kexue·2025
Same author

Effectiveness and safety of community-led assisted partner service among HIV-diagnosed men who have sex with men: a multicentre, randomized controlled trial in China.

The Lancet regional health. Western Pacific·2023
Same author

DNA topology regulates PAM-Cas9 interaction and DNA unwinding to enable near-PAMless cleavage by thermophilic Cas9.

Molecular cell·2022
Same author

Consensus statement on human immunodeficiency virus pre-exposure prophylaxis in China.

Chinese medical journal·2020
Same author

In vitro characterization of the metabolic pathways and cytochrome P450 inhibition and induction potential of BMS-690514, an ErbB/vascular endothelial growth factor receptor inhibitor.

Drug metabolism and disposition: the biological fate of chemicals·2011
Same author

Evaluation of primary HPV-DNA testing in relation to visual inspection methods for cervical cancer screening in rural China: an epidemiologic and cost-effectiveness modelling study.

BMC cancer·2011

Related Experiment Video

Updated: Jul 12, 2026

Establishing a Device for Sleep Deprivation in Mice
05:05

Establishing a Device for Sleep Deprivation in Mice

Published on: September 22, 2023

Simulated shift work Schedules disrupts circadian rhythms and behavior in mice.

Jun-Yi Duan1, Xiao-Tong Huang1, Ai-Yu Duan1

  • 1PLA Naval Medical University, Shanghai, China.

Function (Oxford, England)
|July 10, 2026
PubMed
Summary

Shift work disrupts the body's internal clock, leading to weight gain, hormonal imbalances, and gut microbiome changes. This circadian rhythm disruption causes increased anxiety, depression, and fatigue in mice.

Keywords:
Circadian rhythmClock geneGut microbiomeMoodShift work

More Related Videos

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System
07:34

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System

Published on: December 16, 2022

Related Experiment Videos

Last Updated: Jul 12, 2026

Establishing a Device for Sleep Deprivation in Mice
05:05

Establishing a Device for Sleep Deprivation in Mice

Published on: September 22, 2023

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System
07:34

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System

Published on: December 16, 2022

Area of Science:

  • Chronobiology
  • Metabolic Health
  • Neuroscience

Background:

  • Shift work is prevalent, causing circadian rhythm disruption.
  • Disrupted circadian rhythms are linked to various health issues.

Purpose of the Study:

  • To investigate the systemic health consequences of shift work-induced circadian disruption.
  • To analyze the impact of altered light-dark cycles on central and peripheral physiology.

Main Methods:

  • Mice were exposed to different light-dark cycles (non-24h vs. 24h).
  • Evaluated behavioral changes, serum hormone levels, SCN gene expression, and gut microbiome composition.
  • Utilized transcriptomic analysis, GO, and KEGG enrichment analyses.

Main Results:

  • Non-24h cycles caused body weight gain and loss of core clock gene rhythms in the SCN.
  • Circadian rhythms of melatonin and dopamine were abolished.
  • Gut microbiota dysbiosis and loss of diurnal oscillations were observed.
  • Increased anxiety-like, depression-like behaviors, and fatigue were noted.

Conclusions:

  • Circadian disruption from shift work leads to multi-system pathology.
  • SCN disruption, hormonal imbalance, and gut dysbiosis are interconnected.
  • Findings highlight the health risks of shift work and inform future schedule design.