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Related Experiment Video

Updated: Jul 12, 2026

Intracranial Subarachnoidal Route of Infection for Investigating Roles of Streptococcus suis Biofilms in Meningitis in a Mouse Infection Model

Intracranial Subarachnoidal Route of Infection for Investigating Roles of Streptococcus suis Biofilms in Meningitis in a Mouse Infection Model

Published on: July 1, 2018

Sulfasalazine-induced aseptic meningitis.

Emily McHale¹, Andrew Dermawan¹, Raymond Tang²

¹Department of General Medicine, G Block, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.

Modern Rheumatology Case Reports

|July 10, 2026

Summary

Sulfasalazine can cause drug-induced aseptic meningitis, a rare condition characterized by meningeal inflammation. This case highlights the importance of considering sulfasalazine as a potential cause when meningitis symptoms appear after starting the drug.

Keywords:

DIAM DMARD Drug reaction SIAM Sulfasalazine

Related Experiment Videos

Last Updated: Jul 12, 2026

Intracranial Subarachnoidal Route of Infection for Investigating Roles of Streptococcus suis Biofilms in Meningitis in a Mouse Infection Model

Intracranial Subarachnoidal Route of Infection for Investigating Roles of Streptococcus suis Biofilms in Meningitis in a Mouse Infection Model

Published on: July 1, 2018

Area of Science:

Neurology
Rheumatology
Pharmacology

Background:

Aseptic meningitis presents as meningeal inflammation without a clear infectious cause.
Drug-induced aseptic meningitis is a known adverse effect of various medications.
Sulfasalazine-induced aseptic meningitis is rarely reported.

Purpose of the Study:

To report a case of aseptic meningitis potentially induced by sulfasalazine.
To raise awareness among clinicians about this rare adverse drug reaction.

Main Methods:

A case report of a male patient in his 60s is presented.
Cerebrospinal fluid analysis revealed mononuclear pleocytosis, elevated protein, and normal glucose.
Cerebrospinal fluid testing excluded bacterial and viral meningitis.

Main Results:

The patient developed aseptic meningitis one month after initiating sulfasalazine for seronegative arthritis.
Cerebrospinal fluid findings were consistent with aseptic meningitis.
Symptoms resolved upon discontinuation of sulfasalazine.

Conclusions:

Sulfasalazine should be considered a potential cause of aseptic meningitis in patients presenting with relevant symptoms.
Early recognition and cessation of the drug can lead to symptom resolution.